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Scientist/Senior Scientist, Discovery Chemistry

Company: Mersana Therapeutics, Inc.
Location: Cambridge
Posted on: January 16, 2022

Job Description:

Scientist/Senior Scientist - Discovery Chemistry Mersana Therapeutics is a clinical-stage biopharmaceutical company using its differentiated and proprietary ADC platforms to rapidly develop novel ADCs with optimal efficacy, safety and tolerability to meaningfully improve the lives of people fighting cancer. Mersana's lead product candidate, upifitamab rilsodotin (UpRi, XMT-1536), is in the expansion portion of a Phase 1 proof-of-concept clinical study in patients with ovarian cancer and NSCLC adenocarcinoma. In 2021, Mersana intends to initiate a single-arm registration enabling strategy in platinum resistant ovarian cancer (UPLIFT) as well as a combination study in earlier lines (UPGRADE). XMT-1592, Mersana's second ADC product candidate targeting NaPi2b-expressing tumors, was created using Mersana's customizable and homogeneous Dolasynthen platform and is in the dose escalation portion of a Phase 1 proof-of-concept clinical study. The Company's early-stage programs include XMT-1660, a Dolasynthen ADC targeting B7-H4, as well as XMT-2056, a STING-agonist ADC developed using the Company's Immunosynthen platform. In addition, multiple partners are using Mersana's Dolaflexin platform to advance their ADC pipelines. Mersana's mission is to discover and develop life-changing antibody-drug conjugates for patients fighting cancer. We seek individuals who share our excitement about the possibilities our proprietary drug conjugation platforms offer, as well as our commitment to making a meaningful difference for patients and their families. At Mersana we have a highly collaborative culture and believe that our collective ability to make a difference exceeds the sum of our individual efforts. Mersana has an exciting new opportunity to join our growing organization as a Scientist or Senior Scientist in the Discovery Chemistry group. S/he/they will be pushing the limits on what can be done with ADCs, building on key advancements exemplified with the immunosynthen platform. We aim to look beyond traditional cytotoxins and identify other drugs which would benefit from a targeted delivery strategy. Take the next step and be at the forefront of the exciting world of ADCs! Key responsibilities in this role will include:

  • Design, synthesis, purification, and characterization of target compounds.
  • Accurate and thorough record keeping, contributing to patent applications and publications
  • Effectively communicating plans and progress to both internal and external scientific audiences.
  • Contributing to chemistry strategy aligned with project objectives.
  • Developing SAR through data analysis and analog design.
  • Demonstrating a strong learning ability by mastering new or unfamiliar areas of science.
  • Acting as a team player, demonstrating flexibility and commitment to achieve project and company goals. How do you know if you're the right fit?
    - You:
    • Have a Ph.D./Postdoc in synthetic organic chemistry (0-5 years industry experience), with a strong record of accomplishment.
    • Have knowledge and understanding of safe operating practices in the laboratory.
    • Are proficient in experimental design and use of laboratory equipment, and are familiar with modern analytical techniques for characterizing compounds.
    • Have experience in synthetic route design.
    • Are highly organized, with excellent record keeping and data management skills.
    • Have the ability to influence workflows and outcomes, based upon past industrial/academic experiences.
    • Must have strong interpersonal skills and an ability to collaborate across disciplines, as well as having excellent written and oral communication skills. The other stuff:
      • You proactively share expertise and ideas, demonstrating flexibility and open-mindedness.
      • You work in an open, collaborative manner, showing respect for colleagues and their ideas.
      • You work effectively as part of a team, and communicate with colleagues at all levels.
      • You are candid and honest in discussions.
      • You are reliable, showing commitment to team goals and guidelines.
      • You have a positive attitude, maintaining consistent work level and motivation, even in the event of negative results.
      • You readily acquire new skills and techniques.
      • Experience with championing a project or initiative is desirable, but not required.
      • Experience managing outsourced chemistry projects is desirable, but not required. Position is eligible for bonus, option awards, and benefits, including medical, dental, and life insurance, 401(k) participation, vacation, and paid holidays. Successful candidate must be authorized to work in the United States. Mersana Therapeutics, Inc. is an equal opportunity employer.

Keywords: Mersana Therapeutics, Inc., Cambridge , Scientist/Senior Scientist, Discovery Chemistry, Other , Cambridge, Massachusetts

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