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Senior Associate Scientist, Upstream Process Development

Company: Solid Biosciences, Inc.
Location: Cambridge
Posted on: January 12, 2022

Job Description:

Position: Senior Associate Scientist, Upstream Process Development Location: Cambridge, MA
Job Id: 210707 # of Openings: 1 Summary:
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Solid's Start: Solid is the English translation of Eytan, the Hebrew name of Solid's co-founders Ilan and Annie Ganot's son, Eytani, who was diagnosed with Duchenne muscular dystrophy (Duchenne) in 2012 at the age of two. Unsatisfied with the existing Duchenne treatment landscape, the Ganots built a disease-focused company with the people and potential to advance innovative science quickly and responsibly.
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Solid's Culture: -Much of what you can learn about Solid and our culture can be found in our name. We come to work each day for the Duchenne community, and that community is our family. We have a collective strength and determination that propels us to embrace innovation and challenge the status quo because central to all that we do is the unwavering commitment to advance meaningful therapies for the Duchenne community. We are a fiercely passionate and committed team, driven to collaborate with thoughtfulness and respect. We value exceptional skills, scientific curiosity, entrepreneurial spirit, diversity and adaptability. #TogetherWeAreSolid in our mission to find a cure for Duchenne muscular dystrophy and we will not stop until we've done it.
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Solid Biosciences is seeking an associate scientist to join our Manufacturing and Process Development team and contribute to the development of our upstream Phase III and commercial viral vector manufacturing process. This individual will join a dynamic and motivated team to develop and characterize unit operations in support of a mid to late stage viral vector program, as well as tech transfer of the process to the clinical/commercial manufacturing team.

The successful candidate will support experiments supporting development, characterization, scale-up, and transfer of the upstream manufacturing processes. They will also be responsible for evaluation and implementation of new and existing technology.
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Key Duties & Accountabilities:

  • Work with supervisor to design, plan and conduct cell culture experiments using high throughput cell culture models, benchtop bioreactors and/or pilot scale Single Use Bioreactors
  • Daily monitoring and maintenance of cultures and bioreactor processes, including sampling and performing basic assays
  • Perform data analysis, prepare technical reports, SOPs, internal and external presentations
  • Coordinate with other departments and outside vendors for repair, maintenance, and/or calibration of laboratory equipment and systems
  • Ordering, stocking, and organization of lab supplies
  • Preparation of reagents, media/buffer, and equipment as needed to support experiments
  • Maintain good communication and collaboration with colleagues Core Competencies Required:
    • Organization
    • Communication
    • Problem Solving/Critical Thinking
    • Judgement and Decision-making
    • Adaptability to work in fast-paced work environment Knowledge, Education, Experience & Skills:
      • Bachelor's or Master's degree in Chemical Engineering or related field with 2+ years in the biopharmaceutical industry
      • Experience with bioreactors systems of various scales including spinner tubes, spinner flasks, benchtop bioreactors, WAVE bioreactors, and single-use pilot-scale bioreactors
      • Experience using automated high throughput ambr and benchtop bioreactor systems
      • Experience with cell culture technologies and operations
      • Knowledge of the principles and concepts around bioreactor scale-up
      • Solid understanding and application of scientific and technical knowledge in mammalian cell culture processes
      • The candidate should be self-motivated, accountable, inquisitive, and have excellent organization and communication skills. Travel Commitment: Some Travel May Be Required. -
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Keywords: Solid Biosciences, Inc., Cambridge , Senior Associate Scientist, Upstream Process Development, Other , Cambridge, Massachusetts

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