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Research Associate II/Senior Research Associate, Analytical Development

Company: CRISPR Therapeutics
Location: Cambridge
Posted on: January 12, 2022

Job Description:

Company Overview

CRISPR Therapeutics is a leading gene editing company focused on developing transformative gene-based medicines for serious diseases using its proprietary CRISPR/Cas9 platform. CRISPR/Cas9 is a revolutionary gene editing technology that allows for precise, directed changes to genomic DNA. CRISPR Therapeutics has established a portfolio of therapeutic programs across a broad range of disease areas including hemoglobinopathies, oncology, regenerative medicine, and rare diseases. To accelerate and expand its efforts, CRISPR Therapeutics has established strategic collaborations with leading companies including Bayer, Vertex Pharmaceuticals and ViaCyte, Inc. CRISPR Therapeutics AG is headquartered in Zug, Switzerland, with its wholly-owned U.S. subsidiary, CRISPR Therapeutics, Inc., and R&D operations based in Cambridge, Massachusetts, and business offices in San Francisco, California and London, United Kingdom.

Job Summary

As part of the Regenerative Medicine team, we are seeking a Research Associate II/Senior Research Associate to join an exciting, fast-growing and well-financed company. Successful candidates will be integral in developing stem cell-derived therapies for regenerative medicine. Successful candidates will have strong cellular and molecular biology skills with extensive experience in analytical test methods and pluripotent stem cells. The position requires enthusiasm, passion, self-motivation, analytical mind set, attention to detail, and a desire to create novel therapies for patients.


  • Develop, optimize, and qualify cell-based bioassay/potency assays and characterization assays
  • Conduct time sensitive experiments and analyze data under the direction of a Research Scientist.
  • Conduct key analytical testing (FACS, IHC, ELISA) of differentiated and edited cells.
  • Perform research requiring molecular biology techniques including DNA/RNA analysis, qPCR/ddPCR, and other plate-based assays.
  • Demonstrated experience with aseptic cell culture methods, including cryopreserving, thawing, and expanding cell lines.
  • Analyze data, prepare detailed research reports and present findings to internal groups.
  • Maintain detailed documentation records and author reports, SOPs, batch records and other materials to facilitate tech transfer, manufacturing, and regulatory submissions
    Minimum Qualifications
    • BS or MS in biology or related discipline and 6+ years of relevant academic/industry experience
    • Prior experience with human pluripotent stem cell culture techniques
    • Extensive experience with cell-based assays, PCR, FACS, IHC, and ELISA
    • Prior experience with in vitro assay development
    • Excellent oral and written communication skills
    • Track record of intellectually challenging oneself to enhance scientific abilities
    • Ability to work independently as well as part of a results-oriented research team
    • Highly organized with significant attention to detail and record keeping
      Preferred Qualifications
      • MS in stem cell biology, immunology (T/NK cells), or related discipline and 5+ years of relevant research experience
      • Expertise in analytical testing
        • Passion - Creates an environment where there is a true passion for the vision of CRISPR Therapeutics to bring novel medicines to patients suffering from serious diseases.
        • Entrepreneurial Spirit/Flexibility - An adventurous spirit, exhibiting ingenuity. A readiness in undertaking a task or project with considerable initiative and risk. The ability to adapt to working effectively within a variety of situations.
        • Communication and Teamwork - Effectively express ideas in written, visual and oral context. The ability to work cooperatively with others; the genuine desire to be a part of a team and contribute to team and corporate goals.
        • Results Oriented/Productive Work Habits - Drives issues and tasks to closure and gets the job done. Skilled at analyzing scope of work, as well as planning and executing a successful outcome.
          CRISPR Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.

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Keywords: CRISPR Therapeutics, Cambridge , Research Associate II/Senior Research Associate, Analytical Development, Other , Cambridge, Massachusetts

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