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Scientist, Methods and Process Development

Company: Planet Pharma
Location: Cambridge
Posted on: January 12, 2022

Job Description:

As a Scientist in the Screening Team, you will work with a cross-functional team, building and refining screening methods to meet the needs of our growing therapeutic landscape. You will spearhead the development of novel high-throughput genetic perturbation methods to enable the advancement of emerging technologies. By applying your skills in primary, immortalized and iPSC-derived cell culture, you will become the subject matter expert in genetic perturbation methods for current and emerging in vivo and ex vivo therapeutic targets and a broad spectrum of CRISPR technologies. Your efforts will touch all parts of the organization, from research and development to legal and technical operations. Methods and data generated by you will be at the forefront of the next therapeutic or technological advancement.
As a Screening Team Scientist, you will:

  • Design, execute and troubleshoot high-throughput CRISPR screens in T-cell, primary and immortalized cells with the application of a variety of genetic perturbation methods
  • Have hands-on proficiency with sample preparation for Next-generation sequencing and a knowledge of downstream analysis
  • Develop methods and perform experiments to measure mRNA and/or protein expression via RT-PCR, FACS, ELISA, MSD, ddPCR
  • Provide key input to stakeholders to advance future therapies and technologies
    About You: We are in search of driven and high-energy candidates with a PhD in Cell Biology, Molecular Biology, Immunology or a related field with 0-2 years of post-PhD experience. Strong candidates with Bachelors (6-8 years) or Masters (4-6 years) in related disciplines will also be considered. The ideal candidate has extensive knowledge of CRISPR and experience leveraging high-throughput liquid handling automation in the development, optimization, and validation of bioassays.
    Additional role requirements include:
    • Strong data analysis, interpretation, visualization, and presentation skills
    • Clear and timely communication and documentation of results in electronic lab notebooks
    • Organizational proficiency and ability to plan multiple concurrent workflows
    • Experience and desire to mentor team members by sharing your expertise in experimental design, execution, troubleshooting and interpretation

Keywords: Planet Pharma, Cambridge , Scientist, Methods and Process Development, Other , Cambridge, Massachusetts

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