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Senior Research Scientist, Computational Genomics

Company: Vertex Pharmaceuticals
Location: Cambridge
Posted on: November 22, 2021

Job Description:

Job DescriptionStem Cell Research Senior Scientist - Computational BiologyPosition Summary:We are seeking a senior computational biologist with experience and expertise in driving forward biological discoveries to join Vertex. This position is part of a global Data and Computational Sciences team focused on developing Cell and Genetic Therapy treatments of serious human diseases. You will collaborate closely with a stem cell research group dedicated to discovering and actualizing the next generation of cell therapies for diabetes. You will lead and design genomics studies, develop and apply analyses, and interpret the outcome, while having a critical impact on the development of transformative therapies, and the understanding of pluripotent stem cell biology and pancreatic islet development. You will play a key role in innovating, evaluating, and applying cutting-edge computational methods that will enable us to make rapid, data-driven decisions. Leadership skills, proactive communication, and seamless cross-functional collaboration will be required for success in this role.Key responsibilities:

  • Proactive collaboration with project teams, acting as the bioinformatics expert, to identify key project needs that can be addressed using genomics, sequencing, or bioinformatics contributions
  • Partner with teams to propose and plan studies that leverage sequencing, genetic, and genomic data to answer biological questions and enable development of cell therapy treatments
  • Perform sophisticated computational analyses of sequencing data and other biological data, through deep critical thinking, published findings and best practices from the field, strong statistics, and data science visualizations
  • Distill complex analyses and scientific results into key take-home messages and recommendations for next steps to a broad audience
  • Bring forward and advocate for public advancements in the fast-paced fields of cell therapies and sequencing technologies that would accelerate therapeutic development and/or overcome obstacles
  • Partner with method development team members, identifying opportunities to improve usability, accuracy, and robustness of internal methodsMinimum Qualifications:
    • PhD degree in computational biology, bioinformatics, human genetics, genomics, systems biology, bioengineering, or a related field, with 3+ years of productive, relevant industry or post-doctoral experience
    • Master's degree in computational biology, bioinformatics, human genetics, genomics, systems biology, bioengineering, or a relatd field, with 8+ years of productive, relevant industry experience
    • A proven track record of stand-out excellence in the analysis, visualization, and interpretation of genomic and next-generation sequencing (NGS) data
    • Demonstrated ability to work across cross-functional teams, ensuring timely progress
    • Superior communication skills, demonstrating con---dence and versatility in presenting verbally to diverse audiences and writing technical documents
    • Deep scientific understanding of gene editing, the role of genetic variation in human disease, molecular biology, and cellular biology
    • Expertise with rapidly applying computational methods and bioinformatics tools to large-scale data
    • Proficiency with R and high-performance computing systems; solid understanding of statistics
    • A team-oriented growth mindset that welcomes feedback from others and supports other team members; a positive attitude that enthusiastically tackles and overcomes challenges
    • Experience in analyses of single-cell RNA-sequencing, lineage tracing, and stem cell biology is preferred#LI-KW1Company InformationVertex is a global biotechnology company that invests in scientific innovation.Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at

Keywords: Vertex Pharmaceuticals, Cambridge , Senior Research Scientist, Computational Genomics, Other , Cambridge, Massachusetts

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