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Research Associate (PhD)

Company: Massachusetts General Physicians' Organization
Location: Cambridge
Posted on: November 22, 2021

Job Description:

Job Description - Research Associate (PhD) (3155541) Research Associate (PhD) - ( 3155541 ) The Ruvkun Laboratory (https://www.ruvkun.hms.harvard.edu/ ) in the Department of Molecular Biology at Massachusetts General Hospital (MGH) is seeking a motivated postdoctoral candidate to join our research group.-- The Ruvkun lab pursues C. elegans molecular genetics projects in the fields of small RNAs and viral immunity, and mitochondrial, ribosomal, and proteasomal surveillance. A PhD is required. Letters of recommendation (at least 3) required. Course work or experience in genetics, phylogenetic comparison, and functional genomics are helpful.--Experience in other genetic systems such as yeast genetics, bacterial genetics, Drosophila genetics, or --C. elegans-- genetics very helpful. We are also interested in people who have studied the genetics of diverse bacteria or intensive genetic analysis of more standard bacteria such as E. coli or B. subtilis. Many projects also involve bioinformatics, so experience in computational biology would be highly valued. The Ruvkun lab is best known for its work on microRNAs and their role in translational control and on insulin regulation of --C. elegans-- lifespan.--But over the past two decades, we have discovered that a variety of ancient cellular pathways are surveilled for disruption by microbial toxins to trigger immune responses that include production of antiviral siRNAs.--The engine of the lab is now full genome sequencing of newly generated mutations in large-scale genetic screening. -- Because our genetics constantly sends the lab into new fields, diverse fields are explored in the lab. There are currently 10 members of the lab. -- The Department of Molecular Biology at Massachusetts General Hospital is a dozen faculty members.--The lab has always recruited from diverse training institutions and in this era of racial reconciliation we have redoubled our efforts in this.-- About Massachusetts General Hospital - Department of Molecular Biology The Department of Molecular Biology at Massachusetts General Hospital is a part of both the research community of the hospital and the Division of Medical Sciences of the Harvard Graduate School of Arts and Sciences. Members of the Department carry out basic genetic and molecular biological research on a variety of topics at the cutting edge of the discipline. At present, approximately 170 people, including 13 faculty and over 85 postdoctoral fellows and graduate students comprise the Department of Molecular Biology. The Department is a major component of the Department of Genetics at Harvard Medical School. All Molecular Biology faculty, postdoctoral fellows and graduate students have concurrent appointments at Harvard, mostly in HMS Genetics. Massachusetts General Hospital has a long-standing relationship with Harvard Medical School. MGH was the first teaching hospital associated with the medical school, and continues to play a major role in the clinical and research training of medical students, residents and fellows. The location of the Department of Molecular Biology at MGH reflects the belief that basic biological science and medical research will both benefit from close interaction. The candidate for the Research Technician I or II position(s) will become proficient in the following duties (examples, but not limited to): routine molecular biology (PCR, recombinant DNA cloning, bacterial transformations, etc.), biochemical techniques, mammalian cell culture, assessment of genome editing technologies in bacteria and mammalian cells, DNA sequencing, designing and executing experiments, analyzing and visualizing data, assisting with routine laboratory tasks (organizing, ordering, stocking, etc.), preparing reagents and solutions, developing and optimizing genome editing assays, recording experimental details and results in an electronic notebook, time management, communication skills, and presenting summaries of work or scientific papers in lab meeting and journal club, respectively. PRINCIPAL DUTIES AND RESPONSIBILITIES:

  • Develop study hypotheses
  • Conduct genetic screens for mutants defective in RNA interference and related processes.
  • Lead the interpretation of data and results
  • Regularly communicate project status updates via team meetings
  • Coordinate and interact closely with other scientists on data quality and file management
  • Actively participate in the preparation of manuscripts for publication and present at scientific conferences
  • Assist in peer- and student-mentorship, shares expertise, provides training and guidance as needed
  • Participate within a team of scientists to foster a culture of scientific excellence and collaboration SKILLS/ABILITIES/COMPETENCIES REQUIRED:
    • Sound understanding of statistics and biological concepts coupled with data science skills to collect, clean, analyze and visualize complex biological data
    • Strong analytical skills and the ability to function and communicate effectively in a highly productive multi-disciplinary environment
    • Track record of leading - or playing an important role - in prior scientific publications
    • Computer programming skills helpful (e.g. R, python, genomic analysis tools)
    • Outstanding communication, organization, and time management skills Education and Experience
      • Ph.D. in Genetics, molecular biology, or biochemistry, or other relevant scientific discipline or equivalent experience required.
      • Seven years of progressive lab experience, with about two years working with genetics in any system from bacteria to humans. PREFERRED QUALIFICATIONS:
        • Recognized excellence as evidenced from preprints or peer-reviewed publications
        • Basic familiarity with commonly used machine learning approaches
        • Familiarity and clinical disease entities and epidemiologic approaches to study them
        • Experience in Unix and bioinformatics tools (Python, R, etc.) Familiarity with statistics/models.
        • Demonstrated experience designing computational methods and tools, including prior experience with algorithms relevant to computational biology, with particular preference for experiences involving high-dimensional data analysis. -- SUPERVISORY RESPONSIBILITY
          • Not Applicable Massachusetts General Hospital is an Equal Opportunity Employer.-- --By embracing diverse skills, perspectives and ideas, we choose to lead. Applications from--protected veterans and individuals with disabilities are strongly encouraged.
            Primary Location Work Locations MGH 175 Cambridge 175 Cambridge Street Job Organization Massachusetts General Hospital(MGH) Schedule Full-time Standard Hours 40 Shift Day Job Employee Status Regular

Keywords: Massachusetts General Physicians' Organization, Cambridge , Research Associate (PhD), Other , Cambridge, Massachusetts

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