Senior / Research Associate, Cancer Biology
Company: Relay Therapeutics
Posted on: November 19, 2021
Senior / Research Associate, Cancer Biology Relay Therapeutics
was founded on the premise that protein motion can be leveraged to
create breakthrough medicines, with a drug discovery engine that
was built on advances in detecting and characterizing dynamic
interactions - anywhere on a protein - not just at the active site.
Our team is putting this principle into practice, with the aim of
accelerating the development of medicines that will make a
transformative difference in patients' lives. We don't just stare
hard problems in the face - we go out looking for them. Are you
energized by attempting to do the impossible? We're looking for
you! Energized by the ultimate collaboration between chemistry,
biology, computation, and biochemistry & biophysics, we have the
resources to change the way drugs are discovered and help millions
of people who were previously untreatable. While leveraging protein
motion for drug discovery is a challenge, we are confident that our
team's dedication and urgency will create opportunities that deeply
impact the lives of the patients. We're building a company for the
ages. The Opportunity: We are seeking a self-motivated researcher
who is excited to join our creative, collaborative, and talented
team to drive the discovery of novel small molecule therapeutics in
oncology. In this role, you will design and execute molecular and
cell biology experiments focused on evaluation of candidate
molecules, and development of novel biomarkers. You will interact
and collaborate cross-functionally with scientists in other
departments, including biochemists, chemists, and computational
biologists while growing your understanding of drug discovery and
helping bring medicines to patients.-- Your Role:
- You will work in close collaboration with our dynamic and
passionate multi-disciplinary drug discovery team.
- You will design and perform cellular and molecular biology
experiments to support the biological evaluation of small molecules
therapeutics in oncology.
- You will be in charge of developing, optimizing and conducting
cell-based assays (target engagement, cell proliferation,
reporter-based) to enable medicinal chemistry efforts and structure
activity relationship assessment.
- You will develop and perform target engagement assays from
tumor samples from xenograft and PDX models.
- Your input is valuable and your team will rely on your
expertise and innovative ideas to drive the project forward.
- You will collaborate with CROs for any outsourcing needs and
integrate data analysis.
- You will maintain good written records of laboratory
procedures, results and conclusions.
- You will interpret, summarize, and report your research
findings to the team.
- You will have the opportunity to present your work regularly at
department and company meetings. Your Background:
- You have a BS/MS with 3+ years of industry or academic
experience working in a cancer biology team.
- You have excellent cell culture skills and experience with
developing genetically engineered cell lines using genetic
approaches such as CRISPR knockout/in, RNAi and protein
- You also have a versatile skill set in cancer biology
techniques from molecular biology (RT-qPCR, western blot, in cell
western) to cell-based target engagement assays (HTRF, Alphalisa,
- You are not afraid to roll-up your sleeves to move your project
forward and are comfortable in a rapidly evolving research
environment. Your can-do attitude is contagious.
- You can communicate clearly and enthusiastically your
- You are passionate about drug discovery and thrive in a highly
collaborative environment. We believe in building balanced teams
and a place where our people can be their best self every day. We
encourage people from underrepresented backgrounds to apply.--
Relay Therapeutics is an equal opportunity employer and will not
discriminate against any employee or applicant on the basis of age,
color, disability, gender, national origin, race, religion, sexual
orientation, veteran status, or any classification protected by
federal, state, or local law. Our Culture: At Relay Tx, we believe
that along with our people, our culture is our greatest asset. In
fact we're proud to share we were named as one of the Boston
Business Journal's "Best Places to Work " in 2017, the--#1 place
for small companies --in 2018 & the--#2 place for small companies
--in 2019. To drive that culture, no one will stop you or hold you
back. Instead, we will give you the tools and colleagues to push
forward relentlessly and cheer you on as you go. If this resonates
with you, drop us a line. About Relay Therapeutics Relay
Therapeutics is a clinical-stage precision medicines company
transforming the drug discovery process with the goal of bringing
life-changing therapies to patients. Built on unparalleled insights
into protein motion and how this dynamic behavior relates to
protein function, we aim to effectively drug protein targets that
have previously been intractable, with an initial focus on
enhancing small molecule therapeutic discovery in targeted oncology
and genetic diseases. Our Dynamo platform integrates an array of
leading-edge experimental and computational approaches to provide a
differentiated understanding of protein structure and motion to
drug these targets. We have built a world-class team of leading
experts from each of these disciplines, and they are driven by a
deep collaboration at every step of our drug discovery process. Our
team is equal parts fearless and relentless, with a shared passion
for working collaboratively in intellectually stimulating
environments. If you're excited by the challenge of putting protein
motion at the heart of drug discovery and passionate about making a
difference in the lives of patients, join us!
Keywords: Relay Therapeutics, Cambridge , Senior / Research Associate, Cancer Biology, Other , Cambridge, Massachusetts
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