Synthetic Chemistry Lead

Company: LifeMine
Location: Cambridge
Posted on: November 19, 2021

Job Description:

LifeMine Therapeutics, Inc. is the first biotechnology company exploiting the unique ability of fungi to produce powerful drugs optimized through billions of years of evolution and deploying these molecules for the treatment of intractable human diseases via novel biological mechanisms. The company is using a genome mining and recombinant overexpression approach to mount a massive search for novel drugs through the fungal biosphere. With operations in Cambridge and Gloucester, Massachusetts, LifeMine brings a unique approach to its revolutionary scientific and medical mission.-- Job Summary We are seeking an experienced, highly-motivated synthetic chemist with a passion for tackling audacious challenges, in this case synthesis of natural products and natural product-like molecules. Key foci of this role are (1) development of scalable total syntheses of natural products retrieved from fungi, (2) design and implementation of synthetic routes to intermediates that enable rapid generation of hypothesis-driven natural product analogues to advance programs from lead through clinical candidate nomination, and (3) leadership and mentorship of other scientists. Central to success will be deep knowledge of and ability to leverage modern synthetic chemistry strategies combined with creativity to invent novel transformations and an urgency to drive our mission forward. Experience working at the interface of Discovery and Process Chemistry is a plus. The role will interface very closely with our Medicinal Chemistry group and offers an opportunity to collaborate broadly through our deeply cross-functional research organization. Job Responsibilities

• Leverage modern synthetic chemistry to design, develop, and execute (1) total synthesis of novel, complex natural products and (2) scalable, modular syntheses of key intermediates that enable SAR generation to advance lead optimization goals
• Research current literature to formulate synthetic chemistry strategies. Evaluate and implement new reactions, techniques, and technologies to advance projects
• Demonstrate scientific leadership within the program team and across departments to advance our science
• Lead and manage synthesis efforts / timelines at CROs
• Accurately document experiments and results in laboratory notebooks in a timely fashion
• Maintain a safe and productive laboratory environment
• Prepare and present experimental results, analysis, and plans in research meetings Job Requirements
  • PhD in organic chemistry or related field with 4+ years of industry experience
  • Expert knowledge of and experience with current synthetic methods
  • Well-established track record of conducting innovative drug discovery research as evidenced through publications and patent applications
  • Experience with both direct and lateral management of other chemists
  • Experience with management of CRO resources
  • Knowledge of and commitment to good laboratory and safety practices
  • Excellent written, organizational and documentation skills
  • Ability to communicate strategy and progress effectively with colleagues, managers, and senior leadership
  • Spirit of collaborative research and sense of urgency to enable success in a team environment
  • The successful candidate should be self-motivated, enjoy working in a fast-paced dynamic team environment, and be inspired by our mission to bring first-in-class medicines to patients who need them LifeMine is an Equal Opportunity Employer and Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sexual orientation, gender identity, age, physical or mental disability, veteran status, genetic information, ethnicity, citizenship, or any other characteristic protected by law. We kindly request no solicitations by agencies or firms regarding this role.

Keywords: LifeMine, Cambridge , Synthetic Chemistry Lead, Other , Cambridge, Massachusetts