Sr. Scientist II

Company: Novartis Pharmaceuticals
Location: Cambridge
Posted on: June 12, 2021

Job Description:

9 billion! At Novartis we invest 9 billion USD in research and development annually.

We are Novartis.

Join us and help reimagine medicine!

Job Summary:

We are seeking a highly motivated and skilled in vivo scientist to join the Immuno Modulation (iMOD) group within Novartis Exploratory Immuno-Oncology. We are dedicated to discovering innovative cancer therapeutics and therapeutic formats that transform patient's lives. The successful candidate will become a key individual contributor in a dynamic, multidisciplinary discovery team interrogating a number of novel immuno-oncology targets. The candidate will be expected to generate data that increases our biological understanding of emerging cancer targets. The high-quality data generated will directly impact the discovery of therapies and contribute to the design of future clinical trials. This position will therefore be ideal for those candidates wishing to combine their interest in immunobiology of cancer with their strong desire to discover and help develop therapeutic approaches.

This opportunity is located at the Novartis Cambridge site, and will not have the ability to be located remotely.

Your Key Responsibilities:

• Participate in the design, development, characterization, implementation and validation of relevant immuno-oncology and disease centric in vivo models for identifying and profiling the biologic effects of perturbing inflammatory pathways to understand target biology and impact on disease
• Excel in designing and setting up subcutaneous and orthotopic cancer models to evaluate cellular therapy strategies, including efficacy, PK, PD, and mechanism of action analyses.
• Perform ex vivo assays including immunology-based analysis and pharmaco-dynamic studies tailored to the strategy and target of interest, with an emphasis on FACS analyses on tumor and other tissue samples.
• Document, analyze, and interpret experiments, present results within a multidisciplinary team environment.

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What You'll Bring to the Role:

• BA/MS with at least 2-5 years of prior experience in industry or academia in in vivo physiology, biology, and/or pharmacology
• Excellent hands-on in vivo skills to independently implement rodent oncology models to evaluate efficacy, PK and PD relationships.
• Experience with xenografts, syngeneic models, in vivo assays for pharmacokinetic evaluations, flow analysis and cell culture are a plus.
• Proficiency with in vivo procedures in rodents, including multiple of dose administration (IP, PO, IV, SC), blood and tissue collection, dissection techniques and necropsies.
• Ability to work on complex problems where analysis requires an in-depth evaluation of multiple factors. Scientifically motivated and exercises independent judgment in selecting experimental methods, techniques, evaluation criteria for obtaining results, and data analysis.
• Strong verbal and writing skills for documentation of data, drafting of technical reports, and communication of progress to manager. Meticulous laboratory approach, careful adherence to protocol and excellent lab notebook documentation
• Must be able to communicate and multi-task within a fast-paced team environment with a high degree of self-motivation and organization
• Has a sense of urgency (self-motivation) and flexibility (tolerate changes in priorities/directions)
• Strong analytical and computer skills
• This opportunity is located at the Novartis Cambridge site, and will not have the ability to be located remotely. Relocation Assistance may be available.

Why Novartis?

769 million. That's how many lives our products touched in 2020. And while we're proud of that fact, in this world of digital and technological transformation, we must also ask ourselves this: how can we continue to improve and extend even more people's lives?

We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you're given opportunities to explore the power of digital and data. Where you're empowered to risk failure by taking smart risks, and where you're surrounded by people who share your determination to tackle the world's toughest medical challenges.

Imagine what you could do at Novartis!

Commitment to Diversity & Inclusion:

Novartis embraces diversity, equal opportunity, and inclusion. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Join our Novartis Network:

If this role is not suitable to your experience or career goals but you wish to stay connected to learn more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network

Keywords: Novartis Pharmaceuticals, Cambridge , Sr. Scientist II, Other , Cambridge, Massachusetts