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Associate Scientist, CMC, contract

Company: Generation Bio Co.
Location: Cambridge
Posted on: June 8, 2021

Job Description:


Generation Bio is an innovative genetic medicines company focused on creating a new class of non-viral gene therapy to provide durable, redosable treatments for people living with rare and prevalent diseases. The company's non-viral platform incorporates a proprietary, high-capacity DNA construct called closed-ended DNA, or ceDNA; a cell-targeted lipid nanoparticle delivery system, or ctLNP; and an established, scalable capsid-free manufacturing process. The platform is designed to enable multi-year durability from a single dose of ceDNA and to allow titration and redosing if needed, and our scalable manufacturing process supports our mission to extend the reach of gene therapy to more people, living with more diseases, in more places around the world. Our vision is to make the ravages of genetic disease as imaginary to the next generation as polio feels to children today.

We are a thriving, collaborative, creative community of 120 people with diverse talents, beliefs, and experiences headquartered in Cambridge, Massachusetts.

Delve further. Please visit or follow @generationbio.


Primary responsibilities for this role include:

  • Join a fast-growing team responsible for process development, scale-up and tech transfer of a non-viral gene therapy process to GMP
  • Support execution of critical upstream and downstream studies to support the improvement of Generation Bio's large-scale manufacturing processes
  • Perform material generation in bioreactors and purification of material using standard bioprocessing operations including filtration, chromatography, and TFF
  • Routinely organize, trend, and report development data


  • B.S. in Chemical Engineering, Biotechnology, Biochemistry or related discipline and 0-2 years of relevant experience
  • Experience conducting cell culture is highly desirable
  • Experience working with AKTAs or other purification equipment is highly desirable
  • Strong collaboration and team-working skills
  • Results-driven with excellent attention to details

Desired experience includes:

  • Experience working in an upstream or downstream process development environment
  • Experience conducting routine cell culture or working with bioreactors
  • Ability to work independently and prioritize technical activities
  • Prepare, analyze, and present data internally to cross functional team

Keywords: Generation Bio Co., Cambridge , Associate Scientist, CMC, contract, Other , Cambridge, Massachusetts

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