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Research Scientist I, Histology

Company: Vertex Pharmaceuticals, Inc
Location: Cambridge
Posted on: June 7, 2021

Job Description:

Job Description

Vertex Cell and Gene Therapy (VCGT), is developing stem cell-based cell therapies for type 1 diabetes, and is seeking an outstanding Research Scientist I to join our growing Pathology-Histopathology Team. This full-time role is ideally suited for an individual with outstanding skills and well versed on routine aspects of histology and developing multiplexing assays, assuming a hands-on role within the histology team. The successful candidate is expected to work effectively within cross-functional teams in a global matrix environment at VCGT and support Sr Scientists.

Key Responsibilities:

  • Hands-on experience in designing, developing and troubleshooting histology based assays for paraffin tissues, using methods such as IHC and IF, ISH, supporting internal collaborative efforts.
  • Analyzing preclinical studies of murine and larger animal models.
  • Performs routine histology procedures, including trimming and processing, embedding and sectioning, H&E and special stains as needed.
  • Proficient in using digital pathology scanners (Leica Aperio AT2 and fluorescence).
  • Responsible for data analysis and compilation for all experiments.
  • Collaborates closely with cross-disciplinary teams and external groups, supporting colleagues by generating end point analyses.
  • Authors SOPs, protocols, technical documents.
  • Summarize findings (PowerPoint Decks, reports) and clearly communicates data to peers and management.
  • Maintains accurate experimental records, follows good laboratory and GLP-like practices.

Required Qualifications and Education:

  • PhD in Biological sciences. MS in Biological Sciences with 4+ years' relevant research experience.
  • Highly self-motivated, team player, with proven and excellent interpersonal skills interacting with multidisciplinary teams.
  • A strong applicant will have prior relevant industry experience using multiplexing assays, while assay development will be a strong plus.
  • Experience in histology-based biomarker assay development and validation.
  • Knowledge of extensive statistics, pancreatic islet biology and/or T1 diabetes mellitus would be advantageous.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at

Keywords: Vertex Pharmaceuticals, Inc, Cambridge , Research Scientist I, Histology, Other , Cambridge, Massachusetts

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