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Principal/Senior Principal Scientist, Computational Chemistry

Company: Blueprint Medicines Corporation
Location: Cambridge
Posted on: June 7, 2021

Job Description:

Principal/Senior Principal Scientist, Computational Chemistry

Cambridge, MA

Requisition Number: CHM20-904

At Blueprint Medicines, we are creating a blueprint for the future of healthcare. We are a leading company in the personalized medicine revolution by focusing on delivering new medicines that are targeted to the genetic driver of disease. We do this by leveraging our one-of-a-kind drug discovery platform to discover, develop and work to bring highly-selective kinase inhibitors to patients globally. This prolific scientific platform has enabled Blueprint Medicines to build a pipeline of novel therapies that span three distinct areas of medicine; genomically defined cancers, rare diseases and cancer immunotherapy.

Blueprint Medicines has built an integrated platform that combines genomics expertise with a novel kinase inhibitor library. Blueprint is also actively exploring novel modalities to inhibit kinase function through non-ATP competitive binders and/or degradation pathways as well as considering protein targets outside the kinome. To aid in our mission of rapidly developing highly selective compounds to address clear genomic drivers of disease, we are seeking a motivated scientist with expertise in computational chemistry to join our Drug Discovery team. In this role, the ideal candidate will apply computational chemistry techniques, including molecular modeling, SBDD and cheminformatics methods to support project teams across all stages of drug discovery.


  • Provide computational chemistry support, including SBDD and cheminformatics to on-going drug discovery projects and new target development initiatives
  • Develop novel computational approaches to aid in the systematic identification and interrogation of novel drivers of kinase potency and selectivity using our fully annotated kinase compound collection, alternative mechanisms of action or modalities.
  • Support the development and application of walk-up tools to support medicinal chemists in the design of novel bioactive compounds.
  • Build strong relationships with MedChem & StructBiol scientists with shared ownership and accountability within a design team framework


  • A PhD and 7-12+ years of computational chemistry experience within a pharmaceutical or biotechnology setting is required
  • Demonstrated exemplary skills in all aspects of modern computational chemistry including (receptor-based) structure-based design, conformational analysis, molecular dynamics, QSAR, binding free energy calculations and chemoinformatics
  • Deep experience implementing computational chemistry strategies across all stages of drug discovery from hit identification, hit to lead evaluation and especially lead optimization to achieve program goals
  • Demonstrated understanding of all aspects of modern drug discovery including medicinal chemistry, DMPK principles, multi-parameter optimization, etc.
  • Demonstrated experience functioning within strong multi-disciplinary project teams
  • Demonstrated experience in complex problem solving through in-depth analysis of data
  • Sustained level of high performance and track record of success in the application of computational chemistry techniques to drug discovery programs, as evidenced by patent and publications
  • Experience in kinase inhibitor drug discovery and in-depth experience with molecular dynamics (mixed solvent MD, allosteric/cryptic pockets, long timescale & adaptive sampling) preferred
  • Experience with KNIME and Schrdinger computational software preferred


  • An ability to empower others
  • cross-functional partner, with an ability to communicate
  • A desire to participate in a highly creative and hardworking environment
  • At home in an accountable environment where you can make a clear impact
  • A teammate who listens effectively and invites response and discussion
  • A collaborator who communicates in an open, clear and consistent manner

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.


Blueprint Medicines' mission is to dramatically improve the lives of patients with genomically defined diseases. Our singular focus is to use our deep understanding of the genetic blueprint of cancer and other diseases driven by the abnormal activation of kinases to craft highly selective medicines aimed at eradicating these diseases.

We don't think in small steps. We think in giant leaps.

We are driven by the pursuit of new ideas, new innovations, and new ways of thinking.

We know that what each and every one of us does matters and that our success depends on our ability to work together. We believe we are at our best as a company when our employees are thriving and foster a culture that provides opportunities to grow and develop professionally, while also having fun.

Keywords: Blueprint Medicines Corporation, Cambridge , Principal/Senior Principal Scientist, Computational Chemistry, Other , Cambridge, Massachusetts

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