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Research Associate II/Senior Research Associate, Neuroscience (in vitro)

Company: Voyager Therapeutics
Location: Cambridge
Posted on: June 7, 2021

Job Description:

Reports To

Principal Scientist, Neuroscience

We are Voyager Therapeutics, a company compelled by curiosity and powered by persistence. We are the seekers who specialize in clinical-stage gene therapy, focused on developing life-changing treatments for severe neurological diseases. Voyager is committed to advancing the field of AAV gene therapy through innovation in vector engineering, capsid discovery, manufacturing, and the optimization of dosing and delivery to enable these novel therapies. Our wholly owned and partnered pipeline focuses on severe neurological diseases, such as Parkinson's disease, Huntington's disease, Friedreich's Ataxia and other areas where patient communities are currently underserved. We've been busy, but we've got so much more to discover - such is the life of a Voyager.

If you're someone who thrives on finding the elusive answers to tough questions, come explore with us!

We are seeking an experienced and highly motivated Research Associate II or Senior Research Associate to contribute to our neuroscience research team at our facility in Cambridge, Massachusetts. This is an ideal position for an individual with a strong background in molecular and cellular assays and methods development, who thrives in a team-oriented, fast-paced, and cross-disciplinary small biotech environment. The successful candidate will be lab based and be responsible for the development, implementation, execution, and analysis of ex vivo and in vitro studies to assess expression, distribution, and pharmacodynamic effects in support of multiple therapeutic programs and platform discovery neuroscience research.

Responsibilities

  • Optimize and execute assays to assess expression, distribution, and pharmacodynamic effects of AAV gene therapy candidates in samples from preclinical pharmacology studies in support of multiple development and platform programs
  • Develop and perform molecular and biochemical analyses for the quantitative and qualitative analysis of target proteins, DNA, mRNA, and miRNA in tissue samples from preclinical pharmacology studies
  • Utilize molecular and cell-based assays to identify and validate potential pharmacodynamic and predictive biomarkers of AAV gene therapy drug activity
  • Identify, evaluate, and integrate cutting edge tools and novel bioanalytical methods
  • Provide technical expertise to identify gaps, troubleshoot technical challenges, and develop new and optimize existing assays
  • Independently analyze and interpret data and present in various team formats
  • Integrate and collaborate with internal research teams in a fast paced environment

Minimum Qualifications

  • A BS (with 2-5 years of experience) or a MS (with 1-3 years industry experience) in Molecular/Cellular Biology, Biochemistry, Pharmacology or a similar field
  • Proven experience with molecular and biochemical techniques including various ELISA formats, functional activity assays, ddPCR, RT-qPCR, bDNA, DNA and RNA isolation, Western blot
  • Experience in cell culture techniques and cell based assays; including viral transduction, DNA and siRNA transfection and electroporation
  • Experienced in the development of molecular, biochemical, and cell based assays
  • Independently motivated, detail oriented scientist with excellent critical thinking and problem solving skills
  • Possess outstanding interpersonal skills including written and verbal communication
  • Ability to be highly productive in a collaborative and matrixed team environment
  • Must be organized and able to contribute to multiple parallel work streams

Preferred Qualifications

  • Significant experience with early drug development within a small biotech environment

RECRUITING & STAFFING AGENCIES: Voyager Therapeutics does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Voyager or its employees is strictly prohibited unless contacted directly by Voyager's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Voyager, and Voyager will not owe any referral or other fees with respect thereto.

Keywords: Voyager Therapeutics, Cambridge , Research Associate II/Senior Research Associate, Neuroscience (in vitro), Other , Cambridge, Massachusetts

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