Scientist, Infectious Disease Research
Company: Moderna Theraputics
Posted on: June 7, 2021
This role is an exciting opportunity for an experienced,
talented and motivated Scientist to be part of the vaccine design
and selection team in Moderna Infectious Disease Research. The
Scientist will be responsible for working on discovery and
development of novel mRNA vaccine candidates and support their
advancement to clinical studies. The Scientist will apply expertise
in the fields of biochemistry, biophysics and protein structure to
design, purify and characterize novel protein and mRNA antigens
against infectious disease targets. The Scientist will collaborate
with cross-functional teams, such as computational sciences,
immunology and virology, evaluate their vaccine designs in the lab
with colleagues and present their results internally and
externally. Located in Cambridge, MA, the Scientist should be
outstanding in their expertise, have a proven track record of
vaccine-related research and development, collaborative team
members and an excellent communicator.
Here's What You'll Do:
Design viral and bacterial protein antigens that are stable,
high-yielding and conformationally native.
Express and purify recombinant proteins for use in research
assays and clinical assays.
Develop medium- to high- throughput recombinant protein
expression screening and antigenic characterization using
biochemical and biophysical approaches.
Design mRNA vaccines, validating them in vitro and in vivo.
Work closely with cross-functional teams across the Moderna
ecosystem, collaborators and CROs to progress candidates from
discovery through IND-enabling studies.
Interpret, troubleshoot, and report complex data. Propose novel
vaccine targets aligned with Moderna's scientific strategy and
Maintain expertise in the field of vaccinology, infectious
disease, immunotherapy and therapeutic developments thoroughly
keeping up to date with literature, attend relevant meetings, and
liaise with external experts in the field.
Manage multiple experiments, projects and interactions with
Provide scientific and technical advice to multidisciplinary
- Prepare documents and present strategy, results, project
updates, and summaries.
Here's What You'll Bring to the Table:
Exceptional PhD with expertise in protein expression,
purification and characterization.
Knowledge of vaccinology, virology and immunology is required.
Knowledge and experience in mRNA vaccinology are a plus. We are
particularly interested in candidates who have experience in
biochemistry and structure-based vaccine design.
Expertise and knowledge of cellular and molecular biology (e.g.
cell culture, transfections, transductions, protein chromatography,
western blotting, immunoprecipitation, ELISA and flow cytometry) is
necessary. Expertise in cell line development is advantageous.
Experience in protein production and characterization is
required. Experience with in vitro assays such as serum ELISA and
neutralization assays and experience in design and/or functional
evaluation of antibodies is desirable.
Proven track record of high impact publications and
presentations in the field of protein production, antigen design or
The ability to work in a cross-functional work environment is
critical; strong leadership skills and independence are
Excellent written, presentation and interpersonal communication
skills; ability to influence and collaborate in a team
- Candidate will be curious in exploring new paths for vaccine
and drug discovery, bold in proposing creative experimental designs
and ideas. Will work collaboratively with multifunctional teams and
will be relentless in pursuing successful outcomes.
Here's What We'll Bring to the Table:
- On-site subsidized cafeteria or catered lunches
- Company-provided iPhone
- Free parking, monthly subway pass or a subsidized commuter rail
- Free annual corporate membership to Bluebikes
- Highly competitive healthcare coverage including: medical
offered through BCBS (HMO/PPO), dental, and vision offered through
- Flexible Spending Accounts for medical expenses and dependent
- 16 weeks of 100% paid parental leave for all new parents
- 16 weeks 100% paid family caregiver leave
- 20 weeks 100% paid medical leave
- Eligible for "Moderna Month" (one month paid sabbatical after
five years of service and eligible for additional one month paid
sabbatical every 3 years thereafter)
- Adoption assistance and discounts to local childcare centers,
as well as access to care.com
- 401k (traditional and Roth offered) with 50% match on first 6%
deferred. Match is vested immediately
- A suite of Moderna paid insurance coverage, including: life
insurance, short-term and long-term disability
- Voluntary legal assistance plan
- 15 days' vacation and 7 sick days per year, in addition to a
discretionary winter shut down and 11 company paid holidays
(includes 2 floating holidays)
In 10 years since its inception, Moderna has transformed from a
science research-stage company advancing programs in the
promising-but-still-unproven field of messenger RNA (mRNA), to an
enterprise with its first medicine having treated millions of
people, a diverse clinical portfolio of vaccines and therapeutics
across six modalities, a broad intellectual property portfolio in
areas including mRNA and lipid nanoparticle formulation, and an
integrated manufacturing plant that allows for both clinical and
commercial production at scale and at unprecedented speed. Moderna
maintains alliances with a broad range of domestic and overseas
government and commercial collaborators, which has allowed for the
pursuit of both groundbreaking science and rapid scaling of
manufacturing. Most recently, Moderna's capabilities have come
together to allow the authorized use of one of the earliest and
most-effective vaccines against the COVID-19 pandemic.
Moderna's mRNA platform builds on continuous advances in basic
and applied mRNA science, delivery technology and manufacturing,
and has allowed the development of therapeutics and vaccines for
infectious diseases, immuno-oncology, rare diseases, cardiovascular
diseases and auto-immune diseases. Today, 24 development programs
are underway across these therapeutic areas, with 13 programs
having entered the clinic. Moderna has been named a top
biopharmaceutical employer by Science for the past six years. To
learn more, visit www.modernatx.com.
Moderna is a smoke-free, alcohol-free and drug-free work
Moderna is committed to equal employment opportunity and
non-discrimination for all employees and qualified applicants
without regard to a person's race, color, gender, age, religion,
national origin, ancestry, disability, veteran status, genetic
information, sexual orientation or any characteristic protected
under applicable law. Moderna will make reasonable accommodations
for qualified individuals with known disabilities, in accordance
with applicable law.
Keywords: Moderna Theraputics, Cambridge , Scientist, Infectious Disease Research, Other , Cambridge, Massachusetts
Didn't find what you're looking for? Search again!