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Company: Principia Biopharma Inc.
Location: Cambridge
Posted on: June 7, 2021

Job Description:

Position Overview:

The Immunology and Inflammation Research and Early Development Therapeutic Area in Sanofi is building a world-class immunology team and is seeking highly motivated scientists to identify novel therapies in the fields of Immune Checkpoint Biology, Autoimmunity and Innate Immunity.

We are seeking a highly motivated Scientist to join the Checkpoint Immunology Cluster located in Cambridge, MA

The successful candidate will have broad expertise in immunology and cellular biology, excellent oral and written communication skills, and the ability to learn and acquire new techniques and methodologies. The position is a hands-on, laboratory based role. The candidate is expected to analyze, record and report data, be able to develop new methodologies, and execute projects with appropriate supervision. The candidate will participate in new targets identification and validation to support current and future drug discovery programs. This exciting role will afford scientists the opportunity to be intimately involved in early discovery research and pre-clinical development.

Key Responsibilities:

  • Responsible for independently performing experiments and studies in support of research project for drug discovery goals.

  • Initiate, design, direct and execute experiments, and analyze, interpret and present results.

  • Support drug discovery project working with scientific platform teams and proactively contribute to projects from discovery into early clinical development.

  • Support the development of disease relevant in vitro and in vivo models.

  • Establish in vitro immunological assays to evaluate the biological functions of target molecules in human immune cells.

  • Collaborate with bioinformatics and translational science team to identify and validate the therapeutic targets.

  • Provide and promote support for operational excellence according to Sanofi values and ethics.

  • Prepare publications, research and clinical/regulatory documentation in accordance with Sanofi quality standards.

Essential Qualifications:

  • PhD or Bachelor or Master degree with minimum 12 years of experience in human immunology and in vivo pharmacology.

Preferred Qualifications:

  • Strong background in human immunology and pre-clinical models.

  • Skilled in cell culture and experience with in vitro functional assays using human primary immune cells is highly desirable.

  • Broad experience with immunological and molecular principles and techniques including primary cell isolation/culture, multicolor flow cytometry, cell sorting, ELISA, qPRC, RNA and DNA isolation, immunoblot and lentiviral delivery.

  • Experience working with preclinical animal models of immune diseases.

  • Excellent written and oral communication skills.

  • Excellent interpersonal and team skills; track record of success working collaboratively across disciplines.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.




At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

Keywords: Principia Biopharma Inc., Cambridge , Scientist, Other , Cambridge, Massachusetts

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