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Principal/Sr. Principal Data Scientist

Company: Novartis Pharmaceuticals
Location: Cambridge
Posted on: June 6, 2021

Job Description:

6 Values. Innovation, Quality, Collaboration, Performance, Courage and Integrity

The Early Development Analytics group is searching for a Principal/Sr. Principal Data Scientist. As the successful candidate, you will drive the biomarker strategy for early and late development clinical programs in one or more assigned projects, working closely with interdisciplinary teams to analyze and interpret biomarker data to inform critical project decisions and understand mechanisms of response/resistance to therapy. You will be responsible for designing and executing the biomarker strategy in those programs to inform drug development. You will set the strategy for addressing biomarker issues in early/late phase trials, regulatory submissions and directly influence drug development decisions with internal and external partners.

What you'll be doing?

  • In collaboration with cross-functional quantitative partners, provide quantitative, scientific and strategic input to support the execution of the integrated precision medicine biomarker strategies in drug development.
  • Contribute to planning, execution, interpretation, and communication of innovative exploratory biomarker analyses, to facilitate internal decision making, publications and support submissions
  • Represent the Analytics line functions on cross-functional teams for the assigned projects. Responsible for functional alignment and ensuring line function awareness throughout the assigned activities
  • Participate in interactions with external parties (e.g., key opinion leaders, health authorities), and represent Novartis in statistical discussions at external congresses, conferences and scientific meetings
  • Drive and promote the use of innovative approaches within the organization, through scientific collaborations, publications in scientific peer reviewed journals and presentations at professional meetings
  • Contribute to departmental initiatives (e.g., infrastructure/ process-related or scientific activities)
  • Contribute to the scientific content of materials for internal decision boards/regulatory/submission documents: Briefing Books, decision criteria, trial design(s), responses to Health Authority questions.
  • Collaborate with other line functions. Explain statistical concepts in an easily understandable way to non-statisticians and provide adequate statistical justifications and interpretation of analysis results for actions/decisions/statements, when required.


What you'll bring to the role

  • Advanced degree in bioinformatics, statistics, data science or other quantitative discipline with extensive exposure to bioinformatics. MS with 4+ years relevant work experience or PhD with relevant work experience (including internship)
  • Strong knowledge and understanding of statistical methods such as meta-analysis, mixed effect modeling, longitudinal modeling, time to event analysis, Bayesian methods, bagging/boosting, variable selection methods (e.g., lasso, elastic net, random forest), design of experiments
  • Strong programming skills in R. Demonstrated knowledge of data visualization and exploratory analysis.
  • Good interpersonal and communication skills (verbal and writing), able to work effectively on a multidisciplinary team in a matrix organization


  • Familiarity with statistical and analytical methods for genetics and omics data analysis, and working knowledge of high dimensional exploratory biomarker platforms (e.g., next generation sequencing, transcriptomics, proteomics, flow cytometry, etc.)
  • Experience in the application of bioinformatics methods to drug development
  • Knowledge of scripting languages such as Perl, Python, with expertise in big data, web-based applications, good coding practice, source code management (Git, bitbucket)

Why consider Novartis?

799 million. That's how many lives our products touch. And while we're proud of that fact, in this world of digital and technological transformation, we must also ask ourselves this: how can we continue to improve and extend even more people's lives?

We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you're given opportunities to explore the power of digital and data. Where you're empowered to risk failure by taking smart risks, and where you're surrounded by people who share your determination to tackle the world's toughest medical challenges.

Imagine what you could do at Novartis!

Keywords: Novartis Pharmaceuticals, Cambridge , Principal/Sr. Principal Data Scientist, Other , Cambridge, Massachusetts

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