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Director, In Vivo Pharmacology

Company: Moderna Theraputics
Location: Cambridge
Posted on: June 6, 2021

Job Description:

The Role:

Moderna is seeking a broadly experienced In Vivo Pharmacologist to lead our In Vivo Pharmacology group. This group is responsible for conducting both out-sourced and in-house in vivo rodent studies and operating the Moderna Animal Facility. This individual will embed themselves as the lead in vivo pharmacologist for selected research initiatives related to deeper understanding and optimization of our Platform Technologies, as well exploration of exciting and novel opportunities to advance preclinical research in select therapeutic areas.

Here's what you'll do:

  • In your role as the Leader of the In Vivo Pharmacology group you will provide:
  • Scientific leadership and empowering mentorship to a group of highly skilled in vivo pharmacologists, led by a seasoned Senior Manager, that are engaged in high volume in vivo study execution for multiple preclinical research divisions.

  • Strategic leadership to reports responsible for outsourcing in vivo studies as needed to external in vivo CROs to maximize the capacity and diversity of in vivo pharmacology at Moderna.

  • Empowering guidance to the Senior Manager and her excellent staff who are responsible for maintenance of Moderna Animal Facility for multiple in vivo groups.

  • Support and company ambassadorship for a system put in place to digitally communicate and track in vivo studies which affords reliable stakeholder communication and resource efficiency/accountability to flexibly support Moderna's goals.

  • In your role as the Lead In Vivo Pharmacologist for selected Platform Technology Programs you will:
  • Define the key pharmacology questions critical to each Program's success and then design and critically analyze experiments notable for their scientific rigor, leveraging the expertise of the Platform Statistical Group, to answer these questions.

  • Effectively communicate your data-driven interpretations of the scientific findings to variety of audiences, including senior leaders.

  • Serve as a role model for positive, constructive interactions with the Moderna IACUC.

  • In both roles you will need to
  • Collaborate extensively with colleagues from cross-functional disciplines (chemistry, formulation, nonclinical sciences, cell and molecular biologists, endpoint assay owners) as well as pharmacologists in other pre-clinical divisions. This is a team sport and requires exceptional interpersonal skills.

  • Deftly identify potential issues and creatively problem-solve in a constructive, inclusive manner

Here's What You'll Bring to the Table

  • Education: Ph.D. or DVM specializing in Pharmacology or related discipline (e.g., Immunology, Oncology, etc.)

  • Experience: 10+ years of experience in an In Vivo Pharmacology function, with a significant management component, in the area of drug discovery and development, ideally in nucleic acid or protein therapeutics. A proven track record of overseeing evaluation of drug candidates in in vivo studies as they progress through the early (hit to lead) discovery through lead optimization and into translation to development candidates.

  • Knowledge: The ideal candidate would have excellent knowledge of animal physiology and pharmacology, drug disposition and non-clinical drug studies in the discovery/translational space. Also essential are people management soft skills including coaching, communication and inspirational leadership.

Here's What We'll Bring to the Table:

  • On-site subsidized cafeteria or catered lunches
  • Company-provided iPhone
  • Free parking, monthly subway pass or a subsidized commuter rail pass
  • Free annual corporate membership to Bluebikes
  • Highly competitive healthcare coverage including: medical offered through BCBS (HMO/PPO), dental, and vision offered through VSP
  • Flexible Spending Accounts for medical expenses and dependent care expenses
  • 16 weeks of 100% paid parental leave for all new parents
  • 16 weeks 100% paid family caregiver leave
  • 20 weeks 100% paid medical leave
  • Eligible for "Moderna Month" (one month paid sabbatical after five years of service and eligible for additional one month paid sabbatical every 3 years thereafter)
  • Adoption assistance and discounts to local childcare centers, as well as access to care.com
  • 401k (traditional and Roth offered) with 50% match on first 6% deferred. Match is vested immediately
  • A suite of Moderna paid insurance coverage, including: life insurance, short-term and long-term disability
  • Voluntary legal assistance plan
  • 15 days' vacation and 7 sick days per year, in addition to a discretionary winter shut down and 11 company paid holidays (includes 2 floating holidays)

About Moderna:

In 10 years since its inception, Moderna has transformed from a science research-stage company advancing programs in the promising-but-still-unproven field of messenger RNA (mRNA), to an enterprise with its first medicine having treated millions of people, a diverse clinical portfolio of vaccines and therapeutics across six modalities, a broad intellectual property portfolio in areas including mRNA and lipid nanoparticle formulation, and an integrated manufacturing plant that allows for both clinical and commercial production at scale and at unprecedented speed. Moderna maintains alliances with a broad range of domestic and overseas government and commercial collaborators, which has allowed for the pursuit of both groundbreaking science and rapid scaling of manufacturing. Most recently, Moderna's capabilities have come together to allow the authorized use of one of the earliest and most-effective vaccines against the COVID-19 pandemic.

Moderna's mRNA platform builds on continuous advances in basic and applied mRNA science, delivery technology and manufacturing, and has allowed the development of therapeutics and vaccines for infectious diseases, immuno-oncology, rare diseases, cardiovascular diseases and auto-immune diseases. Today, 24 development programs are underway across these therapeutic areas, with 13 programs having entered the clinic. Moderna has been named a top biopharmaceutical employer by Science for the past six years. To learn more, visit www.modernatx.com.

Moderna is a smoke-free, alcohol-free and drug-free work environment.

Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Moderna will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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Keywords: Moderna Theraputics, Cambridge , Director, In Vivo Pharmacology, Other , Cambridge, Massachusetts

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