Director, In Vivo Pharmacology
Company: Moderna Theraputics
Posted on: June 6, 2021
Moderna is seeking a broadly experienced In Vivo Pharmacologist
to lead our In Vivo Pharmacology group. This group is responsible
for conducting both out-sourced and in-house in vivo rodent studies
and operating the Moderna Animal Facility. This individual will
embed themselves as the lead in vivo pharmacologist for selected
research initiatives related to deeper understanding and
optimization of our Platform Technologies, as well exploration of
exciting and novel opportunities to advance preclinical research in
select therapeutic areas.
Here's what you'll do:
- In your role as the Leader of the In Vivo Pharmacology group
you will provide:
Scientific leadership and empowering mentorship to a group of
highly skilled in vivo pharmacologists, led by a seasoned Senior
Manager, that are engaged in high volume in vivo study execution
for multiple preclinical research divisions.
Strategic leadership to reports responsible for outsourcing in
vivo studies as needed to external in vivo CROs to maximize the
capacity and diversity of in vivo pharmacology at Moderna.
Empowering guidance to the Senior Manager and her excellent
staff who are responsible for maintenance of Moderna Animal
Facility for multiple in vivo groups.
Support and company ambassadorship for a system put in place to
digitally communicate and track in vivo studies which affords
reliable stakeholder communication and resource
efficiency/accountability to flexibly support Moderna's goals.
- In your role as the Lead In Vivo Pharmacologist for selected
Platform Technology Programs you will:
Define the key pharmacology questions critical to each Program's
success and then design and critically analyze experiments notable
for their scientific rigor, leveraging the expertise of the
Platform Statistical Group, to answer these questions.
Effectively communicate your data-driven interpretations of the
scientific findings to variety of audiences, including senior
Serve as a role model for positive, constructive interactions
with the Moderna IACUC.
- In both roles you will need to
Collaborate extensively with colleagues from cross-functional
disciplines (chemistry, formulation, nonclinical sciences, cell and
molecular biologists, endpoint assay owners) as well as
pharmacologists in other pre-clinical divisions. This is a team
sport and requires exceptional interpersonal skills.
- Deftly identify potential issues and creatively problem-solve
in a constructive, inclusive manner
Here's What You'll Bring to the Table
Education: Ph.D. or DVM specializing in Pharmacology or related
discipline (e.g., Immunology, Oncology, etc.)
Experience: 10+ years of experience in an In Vivo Pharmacology
function, with a significant management component, in the area of
drug discovery and development, ideally in nucleic acid or protein
therapeutics. A proven track record of overseeing evaluation of
drug candidates in in vivo studies as they progress through the
early (hit to lead) discovery through lead optimization and into
translation to development candidates.
- Knowledge: The ideal candidate would have excellent knowledge
of animal physiology and pharmacology, drug disposition and
non-clinical drug studies in the discovery/translational space.
Also essential are people management soft skills including
coaching, communication and inspirational leadership.
Here's What We'll Bring to the Table:
- On-site subsidized cafeteria or catered lunches
- Company-provided iPhone
- Free parking, monthly subway pass or a subsidized commuter rail
- Free annual corporate membership to Bluebikes
- Highly competitive healthcare coverage including: medical
offered through BCBS (HMO/PPO), dental, and vision offered through
- Flexible Spending Accounts for medical expenses and dependent
- 16 weeks of 100% paid parental leave for all new parents
- 16 weeks 100% paid family caregiver leave
- 20 weeks 100% paid medical leave
- Eligible for "Moderna Month" (one month paid sabbatical after
five years of service and eligible for additional one month paid
sabbatical every 3 years thereafter)
- Adoption assistance and discounts to local childcare centers,
as well as access to care.com
- 401k (traditional and Roth offered) with 50% match on first 6%
deferred. Match is vested immediately
- A suite of Moderna paid insurance coverage, including: life
insurance, short-term and long-term disability
- Voluntary legal assistance plan
- 15 days' vacation and 7 sick days per year, in addition to a
discretionary winter shut down and 11 company paid holidays
(includes 2 floating holidays)
In 10 years since its inception, Moderna has transformed from a
science research-stage company advancing programs in the
promising-but-still-unproven field of messenger RNA (mRNA), to an
enterprise with its first medicine having treated millions of
people, a diverse clinical portfolio of vaccines and therapeutics
across six modalities, a broad intellectual property portfolio in
areas including mRNA and lipid nanoparticle formulation, and an
integrated manufacturing plant that allows for both clinical and
commercial production at scale and at unprecedented speed. Moderna
maintains alliances with a broad range of domestic and overseas
government and commercial collaborators, which has allowed for the
pursuit of both groundbreaking science and rapid scaling of
manufacturing. Most recently, Moderna's capabilities have come
together to allow the authorized use of one of the earliest and
most-effective vaccines against the COVID-19 pandemic.
Moderna's mRNA platform builds on continuous advances in basic
and applied mRNA science, delivery technology and manufacturing,
and has allowed the development of therapeutics and vaccines for
infectious diseases, immuno-oncology, rare diseases, cardiovascular
diseases and auto-immune diseases. Today, 24 development programs
are underway across these therapeutic areas, with 13 programs
having entered the clinic. Moderna has been named a top
biopharmaceutical employer by Science for the past six years. To
learn more, visit www.modernatx.com.
Moderna is a smoke-free, alcohol-free and drug-free work
Moderna is committed to equal employment opportunity and
non-discrimination for all employees and qualified applicants
without regard to a person's race, color, gender, age, religion,
national origin, ancestry, disability, veteran status, genetic
information, sexual orientation or any characteristic protected
under applicable law. Moderna will make reasonable accommodations
for qualified individuals with known disabilities, in accordance
with applicable law.
Keywords: Moderna Theraputics, Cambridge , Director, In Vivo Pharmacology, Other , Cambridge, Massachusetts
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