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Research Associate/Senior Research Associate, In Vivo Pharmacology

Company: TCR2 Therapeutics Inc.
Location: Cambridge
Posted on: June 1, 2021

Job Description:

At TCR Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage immunotherapy company pioneering the development of novel T cell therapies. Our two lead cell product candidates are being studied in Phase 1/2 trials: TC-210 for solid tumors and TC-110 for hematological malignancies. Our research efforts focus on broadening our pipeline with a series of next-generation enhancements that may further improve clinical outcomes. We are headquartered in Cambridge, Massachusetts and have a clinical manufacturing facility in Stevenage, UK. This role is located in Cambridge, MA.

We are looking for a Research Associate/Senior Research Associate who will report to a Scientist in the In Vivo Pharmacology group. In this role you will perform studies involving engineered T cell therapy of solid and liquid tumors in xenogeneic and syngeneic mouse models. You will be able to learn getting hands-on experience with murine tumor models, including injections, blood and tissue collections, tumor monitoring and data collection. You will also perform in vivo efficacy, PK/PD, and biodistribution studies to advance TRuC T cell development. This position represents an excellent growth and learning opportunity, working closely with experienced scientists in a fast-paced and highly collaborative environment.

Responsibilities:

  • Establish murine tumor models, perform injections, monitor tumor growth, perform necropsy, blood and tissue collections for ex vivo analysis
  • Determine tumor growth kinetics and evaluate efficacy of T cells in xenogeneic and syngeneic mouse tumor models
  • Expand human tumor cells in tissue culture for establishment of tumor models and maintain freezer stocks of these cell lines
  • Perform immunomagnetic purification of T cell populations
  • Transduce T cells with lentiviral vector to produce engineered T cells for in vivo studies
  • Document and analyze experimental data for written or oral presentations

Requirements:

  • BS or MS in Biology or related discipline
  • 1+ years of relevant research experience preferred
  • Experience working with mice: handling, injections, tissue collections required
  • Experience with cell culture desirable
  • Experience with relevant software: Microsoft Word, Excel, Powerpoint
  • Strong record-keeping and data documentation skills
  • The candidate must be well-organized and a team player
  • Outstanding communication, critical thinking and attention to detail is required

Keywords: TCR2 Therapeutics Inc., Cambridge , Research Associate/Senior Research Associate, In Vivo Pharmacology, Other , Cambridge, Massachusetts

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