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Senior Scientist, CAR-T Cell Immunology - Mechanistic Immunology

Company: Novartis Pharmaceuticals
Location: Cambridge
Posted on: June 1, 2021

Job Description:

6 Values. Innovation, Quality, Collaboration, Performance, Courage and Integrity

The Mechanistic Immunology group in Cambridge is an exploratory team within the Novartis Biologics Center (NBC) at NIBR, focused on understanding and exploiting the molecular and immunological mechanisms for the discovery, characterization and optimization of biotherapeutics and gene therapies.

We are seeking a highly motivated and collaborative scientist (Research Scientist II or Senior scientist I) to join our Mechanistic Immunology team and characterize CAR-T cells interactions with tumor cells and the immune system.

What you'll be doing, but limited to

  • Develop and independently execute immunological, cellular and biochemical assays needed to assess and optimize CAR-T cells functionality
  • Conducting ex vivo cell-based assays using T cells and other primary cells from human peripheral blood and tissues to study functional interactions between CAR-T cells, tumor and immune cells
  • Functional characterization of immune responses using experimental methods such as ELISA, ELISPOT and multicolor FACS analysis and new assays to develop.
  • Critically analyze and interpret data, able to prioritize experiments and design follow-up experiments
  • Offer innovative, proactive approaches to scientific questions and troubleshooting efforts
  • Work collaboratively with team members of the Mechanistic Immunology groups and with other collaborators at NBC and Exploratory Immuno-oncology at NIBR
  • Regularly communicate and present results to lab head and teams, prepare protocols and reports
  • Open mentality, ability and eagerness to learn novel techniques or analysis tools based on project needs
  • Maintain familiarity with scientific and technical literature pertinent to the projects

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What you'll bring to the role

  • BSc or MSc in Life Science field, preferably immunology or cell biology/biochemistry with 2-5 years research experience in immunology, cell biology or biochemistry in industry or academia or recent Ph.D. graduate.
  • Solid knowledge and interest in human immunology and cell biology/biochemistry. Experience with primary cell culture, T cell immunology including phenotyping and functional assays and protein biochemistry. Experience in virology is a plus but not mandatory.
  • Demonstrated ability to develop new assays, critically analyze data, learn and combine new techniques and concepts quickly, design experiments and perform exploratory activities
  • Scientific curiosity, initiative, commitment, flexibility and good organization and presentation skills
  • Work independently and as a team member with open communication with the groups and collaborators

Why consider Novartis?

799 million. That's how many lives our products touch. And while we're proud of that fact, in this world of digital and technological transformation, we must also ask ourselves this: how can we continue to improve and extend even more people's lives?

We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you're given opportunities to explore the power of digital and data. Where you're empowered to risk failure by taking smart risks, and where you're surrounded by people who share your determination to tackle the world's toughest medical challenges.

Imagine what you could do at Novartis!

Keywords: Novartis Pharmaceuticals, Cambridge , Senior Scientist, CAR-T Cell Immunology - Mechanistic Immunology, Other , Cambridge, Massachusetts

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