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Scientist, Biochemistry & Nucleic Acid Delivery

Company: Alnylam Pharmaceuticals, Inc.
Location: Cambridge
Posted on: June 1, 2021

Job Description:

Scientist: Biochemistry & Nucleic Acid Delivery


Founded in 2002, Alnylam was built upon a bold vision of turning scientific possibility into reality by harnessing the power of RNAi for human health as an innovative new class of medicines. We are a growing biopharmaceutical company with three approved medicines and a robust pipeline of investigational medicines focused in four strategic therapeutic areas: genetic medicines, cardio-metabolic diseases, infectious diseases, and central nervous system (CNS) and ocular diseases, including several in late-stage development.

Headquartered in Cambridge, Mass., Alnylam employs over 1,500 people in 19 countries and is rapidly growing globally, with additional offices in Norton, Mass., Maidenhead, U.K., Zug, Switzerland, Amsterdam, Netherlands, and Tokyo, Japan. Alnylam is proud to have been recognized as one of The Boston Globe's Top Places to Work six years in a row (2015-2020), a Great Place to Work in the U.K. and Switzerland two years in a row (2019-2020) and a Science Magazine's Top Employer two years in a row (2019-2020). Please visit for more information.

The RNAi Platform group at Alnylam is seeking a passionate, creative scientist to join our team to help advance the delivery platforms for our siRNA based nucleic acid therapeutics. Successful candidate will have a strong background in biochemistry and biology with experience peptide, protein, and antibody discovery and its biophysical characterization. Expertise in assay development, receptor/ligand interactions, protein engineering and protein conjugation would be highly desirable.

Summary of Key Responsibilities

* Characterization of ligand binding using different biochemical and biophysical techniques (eg. surface plasmon resonance (SPR), flowcytometry etc.) * Lead in vitro assay development in cell and cell free systems * Preparation of protein, peptide, and small molecule samples for biophysical studies * Contribute to the maintenance of laboratory equipment * Analyze, interpret, and organize data to prepare clearly articulated experimental reports and communicate the results of the projects at internal and external meetings


* The ideal candidate will have a PhD with 0-3yr or master's degree in Biochemistry with 10yrs of research experience in industry or academic settings * Strong background and in-depth understanding of protein chemistry, biophysical techniques, biochemical characterization of ligand-receptor interactions including binding/uptake * Strong track record of interdisciplinary research and management of multiple projects * The successful candidate will have strong interpersonal skills and a passion for science and the development of new, highly innovative technologies. In a growing and fast-paced environment, this individual must exhibit nimbleness, a willingness to step outside his or her comfort zone, a dedication to constant learning and personal development and thrive in a team environment. * Excellent communication skills (both written and oral) are a must

Alnylam Pharmaceuticals is an EEO employer committed to an exciting, diverse, and enriching work environment.LI

Keywords: Alnylam Pharmaceuticals, Inc., Cambridge , Scientist, Biochemistry & Nucleic Acid Delivery, Other , Cambridge, Massachusetts

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