Associate Engineer, Pilot Plant Operations - CONTRACT

Company: Rubius Therapeutics, Inc.
Location: Cambridge
Posted on: May 3, 2021

Job Description:

Associate Engineer, Pilot Plant Operations - CONTRACT Rubius Therapeutics is a clinical-stage biopharmaceutical company developing a new class of medicines called Red Cell Therapeutics. Our proprietary RED PLATFORM was designed to genetically engineer and culture Red Cell Therapeutics that are selective, potent and off-the-shelf allogeneic cellular therapies for the potential treatment of several diseases across multiple therapeutic areas. Our therapies can potentially be used to kill tumors in cancer and to regulate the immune system for the treatment of autoimmune diseases. We are currently enrolling patients in a Phase 1/2 clinical trial of RTX-240 in patients with relapsed/refractory or locally advanced solid tumors. In addition, RTX-240 is being evaluated in a second Phase 1 arm of the clinical trial for the treatment of patients with relapsed/refractory acute myeloid leukemia, and our IND has been cleared by the U.S. FDA for RTX-321 for the treatment of human papillomavirus 16-positive cancers. We are proud of our passionate, high-performance culture - one based on a set of values that are the cornerstone of who we are and how we hold ourselves accountable. Founded in 2013, we are headquartered in Cambridge, MA, and our manufacturing facility in Smithfield, RI was named 2020 Top 5 Best Places to Work in Rhode Island among medium-sized companies by Providence Business News. We are currently expanding across all functions within the organization. Red blood cells are no longer just for carrying oxygen. Check us out at, or follow us on Twitter and LinkedIn or like us on Facebook. Summary We are seeking an Associate Engineer (contract) to support solution preparation and upstream/downstream processing activities within Pilot Plant Operations team at our Cambridge, MA location. This associate will perform tasks including preparation and characterization of raw material stock solutions, upstream media formulations, and downstream process buffers while also contributing significantly to the buildout of infrastructure, workflows, and procedures needed to ensure consistent delivery of solution requests and traceable documentation of all source materials. This associate will also perform upstream and downstream unit operations for ongoing batches in the Pilot scale environment including shake flask and stirred tank reactor cell culture operations, filtration, cell concentration and buffer exchange. Responsibilities Preparation of chemical reagents, stock solutions, upstream medias, and downstream/formulation buffers. Implementation of and adherence to a lot release criteria program for all stock solutions, upstream medias, and downstream buffers including analytical measurements such as pH, osmolality, density, conductivity, etc. Assist in bioreactor preparation support including pre-build, calibration, and sterilization Perform routine analyzer maintenance activities including calibration, reference checks, routine cleaning or maintenance, troubleshooting and vendor coordination Maintenance, scale up, and troubleshooting of cell culture unit operations in both shake flask and stirred tank bioreactor format. Execution and troubleshooting of downstream unit operations including filtration, cell concentration, and buffer exchange. Data entry into electronic laboratory notebook environment Demonstrate initiative to perform routine solution request coordination with other lab Scientists and Engineers Implementing and documenting new solution preparation procedures Manage raw material inventory including routine inventory checks to prevent stockout Be flexible and comfortable learning new laboratory tasks and equipment Assist other scientists and engineers as needed with complex tasks and experimentation Demonstrate initiative to assure performance of routine testing responsibilities. Conduct lab experiments with and without documented standard operating procedures (SOPs). Ability to work independently with minimal supervisory guidance. Exhibit strong teamwork and communication skills, and flexibility to work in a fast paced and pioneering field. Update SME of progress on frequent basis. Seek additional guidance as needed Ability to logically work through complex issues in a fast-paced environment. Qualifications & Education Preferred B.S. degree in biochemistry, bioengineering, pharmaceutical sciences or related field with 0-2 years' experience in solution preparation, inventory management, or process development activities Strong understanding of and previous experience with aseptic technique Preferred background with solution solubility and reagent preparation Excellent oral and interpersonal communication skills Highly organized and showing initiative in day to day coordination skills Adaptable to a fast changing environment Prior experience with array of analytical techniques to characterize solutions such as pH, osmolality, conductivity, density, and or turbidity measurements EEO Statement: Rubius Therapeutics is proud to be an equal opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. If you have a disability or special need that requires accommodation, please let us know. Recruitment & staffing agencies:Rubius Therapeutics does not accept agency resumes unless contacted directly by internal Rubius Talent Acquisition. Please do not forward resumes to our account, Rubius employees or any other company location; Rubius Therapeutics is not responsible for any fees related to unsolicited resumes.

Keywords: Rubius Therapeutics, Inc., Cambridge , Associate Engineer, Pilot Plant Operations - CONTRACT, Other , Cambridge, Massachusetts