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Associate Director/Director Discovery Toxicology
Takeda fosters a collaborative and stimulating work environment
filled with opportunity and the chance to make a difference in
people's lives. It is a workplace driven by integrity, one of
Takedas long-held values that extends to both the patients we serve
and our employees who develop and deliver medicines. Across our
company, Takeda employees bring together diverse strengths that
together create a stronger whole.
As one of the worlds leading biopharmaceutical companies, Takeda
is committed to bringing Better Health and a Brighter future to
people worldwide. We aspire to bring our leadership in translating
science into life-changing medicines to the next level, in our core
focus areas; oncology, gastroenterology, neuroscience, rare
diseases, plasma-derived therapies, and vaccines. The Greater
Boston Area is headquarters to many of our Global and US business
We are a passionate team doing important work that impacts
patients lives. If you are driven to create better health and a
brighter future, join us!
What makes a successful member of our team? Check out the traits
were looking for and see if you have the right mix.
Life at Takeda
A Global Top Employer
Recognized for our culture and way of working, were one of only
select companies to receive Top Global Employer status for
Associate Director/Director Discovery Toxicology
Job ID R0024727 Date posted 04/20/2021
Location Cambridge, Massachusetts
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information I provide in my application will be processed in line
that all information I submit in my employment application is true
to the best of my knowledge.
Are you looking for a patient-focused company that will inspire
you and support your career? If so, be empowered to take charge of
your future at Takeda. We endeavor to build an industry-leading
Discovery Toxicology program at Takeda. Become a vital contributor
to our inspiring, bold mission by joining as a Discovery
Toxicologist in our Cambridge, MA office.
Our ideal candidate will have a proven track record in prominent
roles supporting cross-functional Discovery teams. She/he is able
to leverage their deep insights into cellular and pathway
mechanisms, coupled with knowledge of toxicology in order to
provide expert advice and direction to improve the quality of
therapeutics. An emphasis in the field of Rare Diseases or
Immunology as well as experience in gene therapy or oligonucleotide
therapy would be a strong plus.
- As part of the Global Discovery Toxicology Team work in
interdisciplinary teams within and across Global Safety to provide
safety support to early discovery teams in Rare Diseases and
Immuno-oncology and engage in core activities within the Discovery
- Work as part of a team of safety assessment scientists and more
broadly DMPK, pathology, pharmacology, and medicinal chemistry
experts to implement discovery toxicology strategy to enable the
selection and progression of optimized drug candidates
- Apply novel toxicity mechanism-based assays and integrated
models to support early target safety and chemistry
- Additional responsibilities include leading or supporting
inter- and intra-departmental initiatives.
- Provide pharmaceutical drug project teams with expert advice
and direction to improve the quality of therapeutics selected for
further development based on proactive risk assessment of target-
and chemotype-related toxicities
- Develop comprehensive target safety reviews with risk
mitigation plan for early drug discovery project teams based on
literature, bioinformatics, and other predictive tools.
- Apply state of the art in silico, in vitro, and in vivo
de-risking strategies to aid in the selection and optimization of
large and small molecule therapeutics, as well as new therapeutic
- Lead the development of early hypothesis-driven investigation
into mechanisms of toxicity for the proactive management of
potential safety liabilities and communication of impact to
EDUCATION, BEHAVIORAL COMPETENCIES AND SKILLS
- Minimum of MS/PharmD with 15+ years of pharmaceutical
experience or PhD in a scientific discipline and 10+ years of
experience working at a pharmaceutical company
- Demonstrated project team experience at a pharmaceutical
company and ability to work effectively in a matrix, global
environment as part of a multidisciplinary team
- Strong problem solver who is highly organized with the ability
to thrive in an environment with rapidly changing priorities.
- Passion to decrease safety related attrition in drug
- Broad scientific knowledge including pharmacology, toxicology,
physiology and biochemistry.
- Experience in development across mixed modalities, especially
oligonucleotides and gene therap and an extensive knowledge in rare
diseases, immunology, and/or oncology is desired.
- Strong interpersonal skills with an ability to develop solid,
long term relationships and the ability to influence others, and
adept at working across multiple cross-functional areas.
- Excellent oral and written communication skills
- DABT certification a plus, but not necessary
This job posting excludes CO applicants
WHAT TAKEDA CAN OFFER YOU:
- 401(k) with company match and Annual Retirement Contribution
- Tuition reimbursement Company match of charitable
- Health & Wellness programs including onsite flu shots and
- Generous time off for vacation and the option to purchase
additional vacation days
Check out where you could be
working if you apply.
Job Seekers: Protect yourself against identity theft
Please be aware there are instances of identity thieves posting
Takeda-branded jobs and posing as employees to steal personal
information. They visit job-related websites and invite candidates
to online chats. During the chat, they press job seekers to provide
bank account information and Social Security numbers.
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