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Director, Proteomics

Company: Flagship Pioneering, Inc
Location: Cambridge
Posted on: May 3, 2021

Job Description:

FL69 Inc. is a privately held, early-stage biotechnology company with the vision to revolutionize the human therapeutic landscape. FL69 Inc. was founded by Flagship Pioneering, a team of entrepreneurial scientists that conceives, creates, resources, and grows first-in-category life sciences companies. Since 2000, Flagship has created over 75 groundbreaking companies that are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna Therapeutics (NASDAQ:MRNA), Seres Therapeutics (MCRB), Syros Pharmaceuticals (SYRS), Rubius Therapeutics (RUBY), Evelo Biosciences (EVLO), Kaleido Biosciences (KLDO), and Indigo Agriculture. FL69 Inc. is a highly dynamic, entrepreneurial, and innovation-driven organization seeking to hire an exceptional scientist to join our team.Position Summary: FL69 is seeking a highly dynamic and innovative candidate to build and lead a Proteomics group responsible for the discovery and validation of new therapeutic targets. This individual will be responsible for assembling and leading a world-class team to develop discovery and targeted validation proteomics specialized in the analysis of non-canonical proteins spanning biomarker discovery, proteogenomics or protein-protein interactions. The ideal candidate for this position has a strong background in LC-MS/MS and a deep understanding of existing and emergent proteomics methods. The ideal candidate must be independent, goal-oriented, have excellent communication skills, be motivated to learn new skills, and be driven to work in a fast-paced entrepreneurial and collaborative environment. The candidate will work closely with the FL69 origination team to establish the early-stage company platform, vision and processes.Key Responsibilities: Build an innovative proteomics team and platform for target discovery and validationDesign, develop and evaluate large scale proteomics-based studies to discover and evaluate non-canonical proteins and therapeutic targets from primary human tissuesDrive innovation surrounding proteomics-based technologies and workflowsLead efforts to adopt and advance ancillary technology across the platform as well as automationGenerate high quality datasets for machine learning & therapeutic discovery from various disease tissues and experimental settingsProvide leadership and overall management of technical teamsMinimum Qualifications:PhD in Molecular Biology, Biochemistry, or related field, with 8-10 years of postdoc and industrial experienceDemonstrated ability in working with highly skilled and intellectually diverse teams in an industry or academic environmentDriven to develop a transformative therapeutic discovery and target validation platformDemonstrated industry or academic achievement, as evidenced by publications in high impact journals, conference proceedings, or widely used codebaseExcellent communication and presentation skills, capable of conveying technical information in a clear and thorough mannerConfident execution, focused and team-oriented with an ability to thrive in an entrepreneurial environmentStrong collaborative skills with evidence of working in and leading a teamDeep expertise in applying proteomics to the discovery and translational space, leveraging high-throughput quantitative proteomics methodologies such as protein-protein interaction analysis and LC-MS/MS based technologiesExperience with a variety of proteomic tools, including deep proteome profiling and quantitation, PTM analysis, immunopeptidomics (MHC I), subcellular localization, protein secretion, plasma membrane profiling, plasma profiling and biomarker discoveryProven track record in developing and implementing biochemical workflows to enrich for target protein groupsFlagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.Will you now or in the future require sponsorship for employment visa status (e.g., H-1B visa status)? *If you'll require the company to commence ("sponsor") an immigration or work permit case in order to employ you, either now or at some point in the future, then you should select Yes. Otherwise, select No.--Do you currently reside within the continental United States? *--SDL2017

Keywords: Flagship Pioneering, Inc, Cambridge , Director, Proteomics, Other , Cambridge, Massachusetts

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