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Scientist/Engineer or Sr Scientist/Sr Engineer, Downstream Process Development

Company: TCR Therapeutics
Location: cambridge
Posted on: May 3, 2021

Job Description:

At TCR Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage immunotherapy company pioneering the development of novel T cell therapies. Our two lead cell product candidates are being studied in Phase 1/2 trials: TC-210 for solid tumors and TC-110 for hematological malignancies. Our research efforts focus on broadening our pipeline with a series of next-generation enhancements that may further improve clinical outcomes. We are headquartered in Cambridge, Massachusetts and have a clinical manufacturing facility in Stevenage, UK. This role is located in Cambridge, MA.

We are growing rapidly and expanding our capabilities, as a result we are looking to add a Scientist/Sr. Scientist to join our Viral Vector team within Process Development. You will report to our Associate Director of Vector Process Development and work closely across the Process Development group on the purification of lentiviral vectors and will work on the latest technologies. You will have the unique opportunity to play a visible role in building and developing a robust and scalable manufacturing process. The role will provide you with advancement to your career development as we enter the next phases of manufacturing and growth. The Process Development team is experienced, highly driven, and a close team and we operate in a highly collaborative environment. We are open to exploring talent and aligning with the right level to set them up for success!


  • Help develop, optimize, andscaledownstream purification processes forviral vectors
  • Optimize parametersthroughwell-defineddesign of experiment studies
  • Analyze and document scientific results for IND enabling study content
  • Mentor and lead associates during execution of internal and external tasks
  • Write protocols andreports to supporttechnology transfersfrom process development to manufacturing
  • Organize and prioritize work to meet timelines with ability to execute on multipleprojects
  • Represent TCR2at scientific presentations and meetings


  • MS orPh.D. inchemical engineering, biochemical engineering, or related discipline. With an MS5+years ofindustryexperience, Ph.D. 2+ years of industry experience is preferred
  • Technical experience with purification applications, including extensive knowledge of filtration and chromatography applications. Additional experience with formulation and fill/finish activities is preferred
  • Experience with tech transfer and GMP manufacturing systems isrequired
  • Experience leading small teamsin lab experimental execution is preferred
  • Outstanding critical thinking and organizational skills, leadership, and attention to detail
  • Desire to build a scalable manufacturing process and be a part of a growing company
  • Team player interested in a fast-paced, exciting, collaborative environment

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Keywords: TCR Therapeutics, Cambridge , Scientist/Engineer or Sr Scientist/Sr Engineer, Downstream Process Development, Other , cambridge, Massachusetts

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