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Plant Engineer II

Company: Alnylam Pharmaceuticals, Inc.
Location: cambridge
Posted on: May 3, 2021

Job Description:


Alnylam is the world's leading RNA interference (RNAi) company.

Founded in 2002, Alnylam was built upon a bold vision of turning scientific possibility into reality by harnessing the power of RNAi for human health as an innovative new class of medicines. We are a growing biopharmaceutical company with three approved medicines and a robust pipeline of investigational medicines focused in four strategic therapeutic areas: genetic medicines, cardio-metabolic diseases, infectious diseases, and central nervous system (CNS) and ocular diseases, including several in late-stage development.

Headquartered in Cambridge, Mass., Alnylam employs over 1,500 people in 19 countries and is rapidly growing globally, with additional offices in Norton, Mass., Maidenhead, U.K., Zug, Switzerland, Amsterdam, Netherlands, and Tokyo, Japan. Alnylam is proud to have been recognized as one of The Boston Globe's Top Places to Work six years in a row (2015-2020), a Great Place to Work in the U.K. and Switzerland two years in a row (2019-2020) and a Science Magazine's Top Employer two years in a row (2019-2020). Please visit for more information.

As a member of Alnylam's Engineering Team, the Plant Engineer will support and act as a subject matter expert for the mechanical, electrical, plumbing and fire protection (MEP & FP) utilities and infrastructure serving Alnylam's Laboratory, Administrative and Manufacturing Facilities in Cambridge and Norton, MA. This position will primarily support Alnylam's Cambridge Locations with occasional responsibilities and on-call back-up for the Alnylam Manufacturing Site in Norton, MA. Inter-site travel within Massachusetts is required.

Key Responsibilities

* Act as responsible engineer for systems and infrastructure including, but not limited to, city water, chilled and hot water, plant steam and boiler plants, fire suppression, building envelope, electrical and waste (aqueous and organic) systems. * Provide technical leadership for capital projects, including utility and equipment design, project management, and project engineering. Drive projects to completion to meet quality, timeline and budget objectives. Manage all assigned equipment design, procurement and startup, including specification development, procurement activities, FAT/SAT, installation, commissioning, debugging, optimization and validation support. * Develop, champion, and directly execute small to medium sized MEP / FP focused site projects, interfacing with Alnylam stakeholders and external consultants / contractors. * Evaluates existing systems across the sites for potential safety enhancements, operational cost reductions or reliability improvements. * Provide technical support, operational assistance, troubleshooting and leadership as required to other allied internal and external groups at Alnylam to maximize reliability and compliance associated with MEP/FP Systems. * Aligns and collaborates with EHS and Facilities for compliance with all local, state and federal standards and reporting. Includes compliance with Alnylam's OSHA Process Safety Management (PSM) Procedure and MassDEP Permits. * Experience with oligonucleotide reagent handling systems and NFPA design / code standards is desirable. * Collaborate with Automation Engineering and Facilities colleagues for building automation system optimization and efficiency. Experience with Siemens, Johnson Controls and/or Delta Building Automation System is desirable. * Manage, review, and update engineering documentation for new capital projects and existing infrastructure, including P&IDs, specifications, and engineering change management. * Assists with the development and implementation of an engineering standards and specifications documents.


* Bachelor's degree in Chemical, Mechanical, Industrial, Marine Engineering or related technical field. * 5 years of relevant work experience - including design, capital projects, and operations support for the biopharmaceutical and/or other mission critical industries. * Knowledge of MEP & FP systems such HVAC (clean, lab and general), high pressure steam, natural gas, electrical and fire detection/suppression. * Knowledge of central plant system operations and utility infrastructure. * Strong understanding of GMPs (CFR, EudraLex) and good engineering practice (GEP), ASME BPE, ASTM E2500, ISPE guidance, etc.

Alnylam Pharmaceuticals is an EEO employer committed to an exciting, diverse, and enriching work environment.

Keywords: Alnylam Pharmaceuticals, Inc., Cambridge , Plant Engineer II, Other , cambridge, Massachusetts

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