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Stem Cell Sr Research Associate

Company: Vertex Pharmaceuticals Inc (US)
Location: Cambridge
Posted on: May 3, 2021

Job Description:

Vertex seeks a talented Senior Research Associate to join the Vertex Cell and Genetic Therapies (VCGT) stem cell research group in Boston, MA. The group’s mission is to discover and actualize the next generation of cell therapies for diabetes. We are looking for a candidate with a strong background in stem cell culture, targeted somatic cell differentiation (to any lineage), and/or stem cell genetic engineering experience to support our team. The ideal candidate is scientifically independent, confident, and accustomed to taking initiative. The position requires strong communication and organization skills, but also proven adaptability and multitasking capability.

Key Responsibilities:

  • Perform human pluripotent stem cell culture to support diverse needs within the group (e.g., various culture formats and scales).

  • Independently prepare for and execute stem cell differentiation campaigns (periodic weekend work is required).

  • Execute gene editing plan and drive subsequent clone expansion.

  • Perform bioassays to evaluate cell culture and differentiation performance.  

  • Present findings to group, summarize data into reports for supervisor.

  • Generate SOPs and protocol refinements, improvements.

  • Assist with lab management: track cell culture reagents, place orders, prepare media and reagents, continuously work to improve lab operations.

Knowledge and Skills:

  • Significant pluripotent stem cell culture experience (e.g., hESC and/or hiPSC). 2D culture experience is required, and 3D is desirable.

  • Experience performing stem cell differentiation to any cell type.

  • Experience with CRISPR, transposase, TALENS, or other genome modification approaches.

  • Competency with cell-based assays such as flow cytometry, ICC, glucose stimulated insulin release assays (GSIS), qPCR, ELISA.

  • Must possess critical thinking and self-reliance to solve tasks independently.

  • Successful candidate will have outstanding organization and multitasking capability.

  • Candidate must possess flexibility to quickly pivot as projects demand.  

  • The candidate will be accustomed to effectively communicating progress, needs, and problems.

Preferred Education and Experience Levels:

  • Masters Degree (or equivalent degree) in biological sciences and 0-2 years of relevant laboratory experience, or

  • Bachelors Degree (or equivalent degree) in biological sciences and 4+ years of relevant laboratory experience


Keywords: Vertex Pharmaceuticals Inc (US), Cambridge , Stem Cell Sr Research Associate, Other , Cambridge, Massachusetts

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