Stem Cell Research Scientist I, Islet Biology

Company: Vertex Pharmaceuticals Inc (US)
Location: Cambridge
Posted on: May 3, 2021

Job Description:

Vertex seeks a Scientist I to join the Vertex Cell and Genetic Therapies (VCGT) Stem Cell Research group in Cambridge, MA. The group’s mission is to discover and actualize the next generation of cell therapies for Type 1 diabetes. We are looking for a candidate with an interest in gaining experience with pluripotent stem cells, principles of development and differentiation, and islet cell biology. The candidate with work closely with the Stem Cell Bio team on a range of discovery projects while interfacing with preclinical and bioengineering sciences. The ideal candidate is scientifically independent and accustomed to taking initiative. The position requires strong communication and organization skills, but also proven adaptability and multitasking capability.

Key Responsibilities:

• Perform human pluripotent stem cell culture and drive discovery research efforts in stem cell and/or islet cell biology

• Lead teams use of analytical tools to evaluate molecular characteristics of stem cells or their differentiated stem cell-derived islets (SC-Islets)

• Execute SOPs and stem cell differentiation campaigns (periodic weekend work is required)

• Work with cross-functional teams to plan, coordinate, and execute experiments

• Present findings to group and broader T1D teams, collaborate to summarize data into reports

Knowledge and Skills:

• Pluripotent stem cell culture experience (e.g., hESC and/or hiPSC). 2D culture experience is required, and 3D is desirable

• Experience performing stem cell differentiation to any cell type  

• Familiarity with cell-based assays such as flow cytometry, western blot, qPCR, ELISA, library prep (scRNA-seq, ChIP-seq, ATAC-seq), Crispr/Cas9

• Must possess critical thinking and self-reliance to solve tasks independently or ask questions

• Successful candidate will have outstanding organization, multitasking capability

• Candidate has proven track record of leading projects

• Must possess flexibility to quickly pivot as projects demand

Preferred Education and Experience Levels:

• BS with 6+ years relevant experience, or

• MS with 3+ years relevant experience, or

• PhD in Cell and Molecular Biology or related discipline

Keywords: Vertex Pharmaceuticals Inc (US), Cambridge , Stem Cell Research Scientist I, Islet Biology, Other , Cambridge, Massachusetts