Scientist, Preclinical Research

Company: Generation Bio Co.
Location: Cambridge
Posted on: April 10, 2021

Job Description:

Description: Generation Bio is a biotechnology company leading a new generation of gene therapy. Our proprietary non-viral platform enables durable, redosable gene therapy manufactured on a global scale to expand the reach of gene therapy. Our goal is to bring the life-saving benefits of gene therapy to more people, living with a broader range of diseases, in more places around the world. Our vision is to make the ravages of genetic disease as imaginary to the next generation as polio feels to children today. We are a thriving, collaborative, creative community of diverse talents, beliefs, and experiences relentlessly dedicated to our mission. Founded and launched by Atlas Venture. Headquartered in Cambridge, Massachusetts. Committed to a future where more people can live full lives. Delve further. Please visit?www.generationbio.com?or follow?@generationbio. Summary: Generation Bio seeks an energetic, versatile, and highly motivated Scientist to join our Preclinical Research group. The successful candidate will contribute to our growing pipeline of development candidates and advancement of our non-viral gene therapy platform. The work is focused on cross-functional research to evaluate new therapeutic indications and lead molecules and will include managing in-vivo studies in our internal ACF or with CRO partners, bench work to design/implement new assays in our state-of-the-art cell and molecular biology lab and literature reviews to advance our knowledge in relevant areas of science. Responsibilities: * Develop and execute assays to evaluate transgene expression (e.g. ELISA, Western Blot, IHC) & biological effects (e.g. enzyme activity, signaling pathway activation/inhibition) from tissue samples, plasma/serum and cell culture supernatants/lysates* Identify animal disease models and design & manage studies to assess target protein expression and disease correction* Conduct in vitro experiments including cell culture maintenance, transfection and downstream sample analysis* Manage CRO activities and academic collaborations* Review literature to identify relevant disease targets and platform technologies* Summarize studies in written reports and oral presentations Qualifications: * Advanced degree in a relevant scientific field (e.g. Pharmacology, Molecular/Cell Biology, Immunology, Physiology)* PhD with postdoctoral research, M.S. with 6+ years of relevant experience, or B.S. with 8+ years of relevant experience* Knowledge of gene therapy, liver biology and/or LNP delivery a plus* Proficient in a broad range of assay technologies including protein detection methods, biochemical & enzymatic assays, and imaging methods* Expertise in animal models of human disease; prior experience conducting in vivo studies a plus* Experience with cell culture manipulation techniques (e.g., transfections, cell-based assays)* Excellent lab technique and the ability to work independently to analyze, interpret, and present data* Enthusiasm for exploring new areas of science and ability to multi-task to support multiple projects across platform and disease biology pharmacology* Excellent organizational and time management skills to allow effective division of time between lab work, data analysis/literature review, and team meetings* Ability to work in a highly collaborative, team-based environment* Excellent written and verbal communication skills Position: Full-Time, Exempt EEOC Statement: Generation Bio believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, gender, religion, national origin, gender identity, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Generation Bio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Keywords: Generation Bio Co., Cambridge , Scientist, Preclinical Research, Other , Cambridge, Massachusetts