Scientist, Preclinical Research
Company: Generation Bio Co.
Location: Cambridge
Posted on: April 10, 2021
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Job Description:
Description: Generation Bio is a biotechnology company leading a
new generation of gene therapy. Our proprietary non-viral platform
enables durable, redosable gene therapy manufactured on a global
scale to expand the reach of gene therapy. Our goal is to bring the
life-saving benefits of gene therapy to more people, living with a
broader range of diseases, in more places around the world. Our
vision is to make the ravages of genetic disease as imaginary to
the next generation as polio feels to children today. We are a
thriving, collaborative, creative community of diverse talents,
beliefs, and experiences relentlessly dedicated to our mission.
Founded and launched by Atlas Venture. Headquartered in Cambridge,
Massachusetts. Committed to a future where more people can live
full lives. Delve further. Please visit?www.generationbio.com?or
follow?@generationbio. Summary: Generation Bio seeks an energetic,
versatile, and highly motivated Scientist to join our Preclinical
Research group. The successful candidate will contribute to our
growing pipeline of development candidates and advancement of our
non-viral gene therapy platform. The work is focused on
cross-functional research to evaluate new therapeutic indications
and lead molecules and will include managing in-vivo studies in our
internal ACF or with CRO partners, bench work to design/implement
new assays in our state-of-the-art cell and molecular biology lab
and literature reviews to advance our knowledge in relevant areas
of science. Responsibilities: * Develop and execute assays to
evaluate transgene expression (e.g. ELISA, Western Blot, IHC) &
biological effects (e.g. enzyme activity, signaling pathway
activation/inhibition) from tissue samples, plasma/serum and cell
culture supernatants/lysates* Identify animal disease models and
design & manage studies to assess target protein expression and
disease correction* Conduct in vitro experiments including cell
culture maintenance, transfection and downstream sample analysis*
Manage CRO activities and academic collaborations* Review
literature to identify relevant disease targets and platform
technologies* Summarize studies in written reports and oral
presentations Qualifications: * Advanced degree in a relevant
scientific field (e.g. Pharmacology, Molecular/Cell Biology,
Immunology, Physiology)* PhD with postdoctoral research, M.S. with
6+ years of relevant experience, or B.S. with 8+ years of relevant
experience* Knowledge of gene therapy, liver biology and/or LNP
delivery a plus* Proficient in a broad range of assay technologies
including protein detection methods, biochemical & enzymatic
assays, and imaging methods* Expertise in animal models of human
disease; prior experience conducting in vivo studies a plus*
Experience with cell culture manipulation techniques (e.g.,
transfections, cell-based assays)* Excellent lab technique and the
ability to work independently to analyze, interpret, and present
data* Enthusiasm for exploring new areas of science and ability to
multi-task to support multiple projects across platform and disease
biology pharmacology* Excellent organizational and time management
skills to allow effective division of time between lab work, data
analysis/literature review, and team meetings* Ability to work in a
highly collaborative, team-based environment* Excellent written and
verbal communication skills Position: Full-Time, Exempt EEOC
Statement: Generation Bio believes in a diverse environment and is
committed to equal employment opportunity for all its employees and
qualified applicants. We do not discriminate in recruitment,
hiring, training, promotion or any other employment practices for
reasons of race, color, gender, religion, national origin, gender
identity, age, sexual orientation, marital or veteran status,
disability, or any other legally protected status. Generation Bio
will make reasonable accommodations for qualified individuals with
known disabilities, in accordance with applicable law.
Keywords: Generation Bio Co., Cambridge , Scientist, Preclinical Research, Other , Cambridge, Massachusetts
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