CambridgeRecruiter Since 2001
the smart solution for Cambridge jobs

ASO Lead Scientist

Company: Q-state Biosciences
Location: Cambridge
Posted on: February 25, 2021

Job Description:

Q-State Biosciences is seeking a highly motivated individual to join our Research and Development team in Cambridge, Massachusetts. The candidate will be expected to provide scienti---c expertise and leadership across the portfolio of therapeutic programs by contributing to the design and development of novel therapeutic oligonucleotides intended for the treatment of neurological diseases. The candidate should possess an in-depth understanding of oligonucleotide design and delivery approaches as well as cutting edge nucleic acid chemistries used for therapeutic applications. The candidate should have a track record in pioneering the development of novel oligonucleotide therapeutic technologies and applying oligonucleotide-based therapeutics to CNS disorders. The candidate will advance Q-State's platform technology and will have a deep understanding of the relationship between sequence, chemistry and associated pharmacological properties. Responsibilities

  • Provide scientific leadership on oligonucleotide design and chemistry choices contributing to the selection of lead and development candidate molecules for portfolio
  • Work with team to understand the biodistribution, efficacy and ADME profiles across multiple target sequences and chemistries for establishment of structure activity relationships
  • Contribute to the development of methods for bioanalytical and biomarker assessment to support discovery and preclinical programs
  • Contribute towards planning experimental design and execution of all aspects of assay development to support discovery and preclinical studies
  • Work with program teams to interpret in vivo animal studies for e---cacy/tolerability and PK/PD evaluation
  • Provide strategic guidance to project teams and senior management including evaluation of novel oligonucleotide technologies for design, chemistry and delivery
  • Prepare clear data presentations and reports Qualifications:
    • PhD in biology, chemistry, chemical engineering or related ---eld
    • Relevant experience (5+ years) in novel oligonucleotide therapeutics
    • Outstanding interpersonal skills and verbal and written communication skills
    • Ability to work e---ectively both independently and collaboratively in a dynamic team-oriented environment
    • Ability to work well with external CROs and collaborators with professionalism and discretion
    • Ability to travel to monitor out-sourced studies
    • Outstanding organizational skills/ability to prioritize and deliver in timely fashion

Keywords: Q-state Biosciences, Cambridge , ASO Lead Scientist, Other , Cambridge, Massachusetts

Click here to apply!

Didn't find what you're looking for? Search again!

I'm looking for
in category
within


Other Other Jobs


Packaging Associate
Description: Adecco is currently assisting a local client recruiting for Packaging jobs in East Providence, RI. These Packaging Jobs are temp to hire opportunities, with starting pay rates up to 12.50/hr , plus
Company: Adecco USA
Location: East Providence
Posted on: 03/2/2021

Commercial Install Apprentice - Taunton, MA
Description: Company Overview:At ADT Commercial, we are in the business of helping people and organizations to protect what matters most to them. Building upon ADT's 145-year legacy, we secure the livelihoods and (more...)
Company: ADT
Location: Taunton
Posted on: 03/2/2021

Security Officer - Concord NH
Description: Job Description: Observes and reports activities and incidents at an assigned client site, providing for the security and safety of client property and personnel. Makes periodic patrols to check for irregularities (more...)
Company: Securitas USA
Location: Concord
Posted on: 03/2/2021


Get New Roofing Work Today - Preview Leads In Your Area
Description: Over 25 million homeowners have trusted HomeAdvisor 1800Contractor to help them find quality professionals with the expertise to turn their home improvement
Company: HomeAdvisor
Location: Taunton
Posted on: 03/2/2021

Make up to $20/hour - Deliver with DoorDash - Start Delivering Today
Description: Your time. Your Goals.What is DoorDashAvailable in over 4,000 cities in the U.S., Canada, and Australia, DoorDash is about connecting people with possibilities: bigger savings accounts, wider nets, stronger (more...)
Company: Doordash
Location: Concord
Posted on: 03/2/2021

Bather / Groomer Trainee
Description: YOUR GROOMING CAREER: Start your career in grooming as a Groomer Trainee As a Groomer Trainee in our Grooming Salon, you'll have the opportunity to build personal relationships with your clients each (more...)
Company: PetSmart
Location: Concord
Posted on: 03/2/2021

Motor Transport Operator
Description: Positions Available Across Massachusetts OVERVIEW
Company: Massachusetts National Guard
Location: Salem
Posted on: 03/2/2021

Get New Landscaping Work Today - Preview Leads In Your Area
Description: Over 25 million homeowners have trusted HomeAdvisor 1800Contractor to help them find quality professionals with the expertise to turn their home improvement
Company: HomeAdvisor
Location: Salem
Posted on: 03/2/2021

Benevis: Orthodontist - Amazing Compensation & Relocation Package
Description: Job DescriptionDental
Company: Benevis
Location: Weymouth
Posted on: 03/2/2021

High Demand For Quality Handymen - Get New Clients In Your Area
Description: Over 25 million homeowners have trusted HomeAdvisor 1800Contractor to help them find quality professionals with the expertise to turn their home improvement
Company: HomeAdvisor
Location: Salem
Posted on: 03/2/2021

Log In or Create An Account

Get the latest Massachusetts jobs by following @recnetMA on Twitter!

Cambridge RSS job feeds