Senior Scientist, Genetic Diseases

Company: Relay Therapeutics
Location: Cambridge
Posted on: February 22, 2021

Job Description:

Relay Therapeutics is a new breed of company at the intersection of computation and biotechnology that is committed to creating medicines that will have a transformative impact on patients. We combine unprecedented computational power with leading-edge experimental approaches across the fields of biology, biophysics, chemistry and structural biology. This integration illuminates - for the first time - the full mobility of a protein and provides key insights into how the dynamic nature of a protein's conformation regulates function. The team at Relay is putting this principle into practice, with the aim of accelerating the development of medicines that will make a transformative difference in patients' lives. We don't just stare hard problems in the face. We go out looking for them. Are you energized by attempting to do the impossible? We're looking for you. At Relay, our team is driven by the ultimate collaboration across each of our drug discovery disciplines. Putting protein motion at the heart of drug discovery is a challenge, but we are confident that our team's dedication and urgency will create opportunities that deeply impact the lives of the patients. The opportunity: We are looking for you to make a significant impact in our company as we build out our Rare Genetic Disease pipeline. Do you have drug discovery experience in the Genetic Disease space? Our creative, collaborative, and talented biology team is looking for an innovative and investigative addition to the team to pioneer Genetic Disease research. You will apply cutting edge technology towards the discovery, characterization, and optimization of small molecule therapeutics towards Genetic Disease targets representing high, unmet medical needs. With a deep biological curiosity, you will think critically and keep up with current literature when making intelligent and informed decisions. You will work in our state-of-the-art laboratory, independently and collaboratively within a team. You will be the lead biologist on a multi-disciplinary drug discovery team. Are you ready to build out the Genetic Disease space at Relay? Your role:

• Serve as the biology lead on a multidisciplinary project team. You will be responsible for the design and execution of studies assessing target modulation of lead compounds in vitro and in vivo. Prior experience working with academic collaborators and/or CROs is a must.
• Bring a knowledge base of lysosomal biology and have an understanding of rare genetic diseases and neurological diseases.
• Work in our state-of-the-art laboratory and utilize your molecular biology (cloning, CRISPR/Cas9 editing, shRNA, cell line engineering for overexpression) and cellular biology (qPCR, western blotting, immunostaining) skills to assess mechanism(s) and small molecule modulation of rare genetic disease targets.
• Use your experience of handling iPSCs and primary cells to develop disease appropriate cell based assays for compound evaluation.
• Identify preclinical in vivo models representative of target patient populations in which to evaluate the pharmacodynamics and efficacy of lead compounds.
• Interpret, summarize, and present research findings at internal and external scientific meetings/conferences. Clear communication of your science to biologists and multidisciplinary colleagues alike is a must.
• Proactively review literature to bring in the newest scientific findings, ideas, and methods/technologies for discovery research. Your background:
  • You earned your Ph.D. and have post-doctoral training in Oncology and/or Lysosomal Biology with demonstrated experience in oncology small molecule drug discovery.
  • You have at least 4+ years of experience in biotech/pharma.
  • You're driven with a consistent track record of scientific excellence as reflected by high impact, peer reviewed publications and/or patents.
  • You're a confident and thoughtful leader with a successful track record and passion to mentor and develop your direct reports and teammates.
  • You are comfortable with - and can thrive in - an environment that is constantly changing, frequently uncertain, and where you're in charge of driving project strategies and progression.
  • You have the patience to learn from your team and peers before turning to yourself for all the answers.
  • You've got excellent communication, presentation, and inter-personal skills; your energy is infectious and motivates the team. We believe in building balanced teams and a place where our people can be their best self every day. We encourage people from underrepresented backgrounds to apply.-- Relay Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law. Our Culture: At Relay Tx, we believe that along with our people, our culture is our greatest asset. In fact we're proud to share we were named as one of the Boston Business Journal's "Best Places to Work " in 2017, the--#1 place for small companies --in 2018 & the--#2 place for small companies --in 2019. To drive that culture, no one will stop you or hold you back. Instead, we will give you the tools and colleagues to push forward relentlessly and cheer you on as you go. If this resonates with you, drop us a line. About Relay Therapeutics Relay Therapeutics is a clinical-stage precision medicines company transforming the drug discovery process with the goal of bringing life-changing therapies to patients. Built on unparalleled insights into protein motion and how this dynamic behavior relates to protein function, we aim to effectively drug protein targets that have previously been intractable, with an initial focus on enhancing small molecule therapeutic discovery in targeted oncology. Our Dynamo platform integrates an array of leading-edge experimental and computational approaches to provide a differentiated understanding of protein structure and motion to drug these targets. We have built a world-class team of leading experts from each of these disciplines, and they are driven by a deep collaboration at every step of our drug discovery process. Our team is equal parts fearless and relentless, with a shared passion for working collaboratively in intellectually stimulating environments. If you're excited by the challenge of putting protein motion at the heart of drug discovery and passionate about making a difference in the lives of patients, join us!

Keywords: Relay Therapeutics, Cambridge , Senior Scientist, Genetic Diseases, Other , Cambridge, Massachusetts