Pharmacology Senior Research Associate
Company: Vertex Pharmaceuticals
Location: Cambridge
Posted on: February 20, 2021
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Job Description:
In June 2019, Vertex announced the establishment of a new
research site in the Boston area where research, development, and
clinical manufacturing for cell and genetic therapies will be
primarily based. Cell and genetic therapies represent two rapidly
emerging therapeutic modalities with the potential to treat-and
even cure-several of the diseases Vertex is focused on, including
sickle cell disease, Duchenne muscular dystrophy and type 1
diabetes. Further investment in a research site specifically
designed to advance these programs will be key to Vertex's
continued and sustained leadership in these exciting approaches. At
Vertex Cell and Genetic Therapies (VCGT) our research teams will
bring together the best biology, technologies and enhanced
manufacturing capabilities to ensure we bring these cutting-edge
transformative therapies to patients as quickly as possible.
KEY RESPONSIBILITIES
* Perform in vivo studies to advance our lead research and
development programs
* Conduct dosing (ip, sc, iv, oral gavage), blood sampling and
tissue harvesting
* Record, analyze and present in-life data
* Coordinate sample collection, storage and transportation
* Execute studies using good documentation practices
* Effectively collaborate with a fully integrated team to
facilitate the success of studies and projects
REQUIREMENTS
* BS or MS in pharmacology, animal science, immunology, or related
discipline, preferentially with at least 2-4 years of relevant
industry experience.
* Demonstrated experience in small animal handling, various methods
of dosing and blood collection, anaesthesia, necropsy, tissue
harvesting and familiarity with methodology of in vitro sample
processing.
* Experience in initiating, maintaining, and evaluating preclinical
in vivo models of metabolic disease.
* Able to troubleshoot, solve difficult problems, and develop
process improvements
* Highly organized with attention to detail and good record
keeping
* Excellent communication skills with ability to build open and
collaborative relationships and work effectively as a member of a
multidisciplinary team
* Flexibility in working schedule to accommodate weekend work
Preferred qualifications:
* Experience in evaluating and performing surgeries in established
preclinical models of diabetes, particularly diabetic induction by
streptozotocin.
* Experience with in vivo/ ex-vivo assessment of pancreatic islet
function (oral GTT, IPGTT, IVGTT, GSIS)
* Proficiency with Microsoft Office and GraphPad Prism and
utilizing such programs for statistical analysis
* AALAS affiliation, RLAT accreditation
Keywords: Vertex Pharmaceuticals, Cambridge , Pharmacology Senior Research Associate, Other , Cambridge, Massachusetts
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