Pharmacology Senior Research Associate

Company: Vertex Pharmaceuticals
Location: Cambridge
Posted on: February 20, 2021

Job Description:

In June 2019, Vertex announced the establishment of a new research site in the Boston area where research, development, and clinical manufacturing for cell and genetic therapies will be primarily based. Cell and genetic therapies represent two rapidly emerging therapeutic modalities with the potential to treat-and even cure-several of the diseases Vertex is focused on, including sickle cell disease, Duchenne muscular dystrophy and type 1 diabetes. Further investment in a research site specifically designed to advance these programs will be key to Vertex's continued and sustained leadership in these exciting approaches. At Vertex Cell and Genetic Therapies (VCGT) our research teams will bring together the best biology, technologies and enhanced manufacturing capabilities to ensure we bring these cutting-edge transformative therapies to patients as quickly as possible.

KEY RESPONSIBILITIES

* Perform in vivo studies to advance our lead research and development programs


* Conduct dosing (ip, sc, iv, oral gavage), blood sampling and tissue harvesting


* Record, analyze and present in-life data


* Coordinate sample collection, storage and transportation


* Execute studies using good documentation practices


* Effectively collaborate with a fully integrated team to facilitate the success of studies and projects



REQUIREMENTS

* BS or MS in pharmacology, animal science, immunology, or related discipline, preferentially with at least 2-4 years of relevant industry experience.


* Demonstrated experience in small animal handling, various methods of dosing and blood collection, anaesthesia, necropsy, tissue harvesting and familiarity with methodology of in vitro sample processing.


* Experience in initiating, maintaining, and evaluating preclinical in vivo models of metabolic disease.


* Able to troubleshoot, solve difficult problems, and develop process improvements


* Highly organized with attention to detail and good record keeping


* Excellent communication skills with ability to build open and collaborative relationships and work effectively as a member of a multidisciplinary team


* Flexibility in working schedule to accommodate weekend work



Preferred qualifications:

* Experience in evaluating and performing surgeries in established preclinical models of diabetes, particularly diabetic induction by streptozotocin.


* Experience with in vivo/ ex-vivo assessment of pancreatic islet function (oral GTT, IPGTT, IVGTT, GSIS)


* Proficiency with Microsoft Office and GraphPad Prism and utilizing such programs for statistical analysis


* AALAS affiliation, RLAT accreditation

Keywords: Vertex Pharmaceuticals, Cambridge , Pharmacology Senior Research Associate, Other , Cambridge, Massachusetts