Principal Scientist, Structural Biology

Company: THIRD ROCK VENTURES, LLC
Location: Cambridge
Posted on: February 17, 2021

Job Description:

Principal Scientist, Structural Biology at Faze Medicines Faze Medicines is seeking an exceptional, innovative and highly motivated Principal Scientist: Structural Biology to apply fundamentals of structural biology principles toward the lead discovery efforts for targets identified from our proprietary platform. The successful candidate will influence the company's emerging small molecule drug design organization and contribute to building a strong portfolio of novel drug candidates. As part of the team of scientists at Faze Medicines, this individual will have responsibility for further deploying Faze's drug discovery infrastructure through the implementation of crystallographic techniques toward our targets of interest in collaboration with CRO partners. As part of drug discovery team, this individual will provide expertise in the structural characterization of novel drug targets by integrating a broad understanding of x-ray crystallography with protein dynamics, enzymology and biophysics. The successful individual will join a dynamic, enthusiastic, interdisciplinary, and collaborative team of scientists. We view you as an important team member whose contributions will be critical to our success.-- Your contributions may include:

• Crystallizing, performing X-ray structure determination, and analyzing of important drug targets through working with external collaborators
• Contributing to biophysical analysis, including SPR, thermal melt and biochemical assays
• Working closely with teammates in drug discovery, leveraging a broad range of biochemical and biophysics techniques to understand protein dynamics and structure
• Managing external structural biology collaborations (CROs)
• Collaborating with multi-disciplinary teams including biology and chemistry to develop a structural biology strategy
• Designing crystallography-grade protein constructs and assisting in the optimization of purification protocols
• Providing regular updates to cross-functional teams and helping guide structure-based compound design in close collaboration with chemistry group
• Analyzing, documenting and reporting data clearly and concisely to project teams
• Interacting with, and ensuring productivity of, collaborators and CROs
• Contributing scientifically and technically within the portfolio of drug discovery programs
• Delivering scientific reports and presentations internally or externally as needed
• Participating in various aspects of this fast-pace company, from building out the capabilities, contributing intellectually and to generating data in a fast and efficient manner
• A degree in a relevant subject and experience in the development and execution of structural biology in a biotech/pharma setting (for example, BS/MS in Biochemistry with 7-10 years of experience; Ph.D. with 3-5 years of experience)
• Function in a scientific expert role as part of an interdisciplinary team contributing to the execution of experiments in support of our research activities and project goals.
• Substantial experience interfacing with CRO partners and proven ability to work efficiently in a hybrid model is essential
• Proven experience in contributing to drug discovery programs in a pharmaceutical/biotechnology setting
• Demonstrated ability to solve difficult problems in protein crystallography, structural biology and biophysics
• Demonstrated competency in protein construct design and expression and purification strategies using bacterial, insect, and mammalian hosts
• Strong knowledge of the drug discovery process, with industry experience in implementing hit identification strategies through candidate selection
• Extensive knowledge of protein structure and function, with the ability to clearly communicate structural information to a broad audience
• Experience with related structural techniques (e.g. electron microscopy, small-angle X-ray scattering) is preferred
• Understanding of modeling and molecular dynamics favorably considered
• Commitment to quality, attention to detail, and team player mentality is a must We are an equal opportunity employer offering a competitive salary and benefits package. All applicants should be legally entitled to work for any employer in the U.S. Note to Employment Agencies:--Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited. 29 Newbury Street
  3rd Floor
  Boston, MA 02116
  P (617) 585-2000

Keywords: THIRD ROCK VENTURES, LLC, Cambridge , Principal Scientist, Structural Biology, Other , Cambridge, Massachusetts