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Principal Research Scientist I/II, Neuroinflammation Drug Discovery

Company: AbbVie, Inc.
Location: Cambridge
Posted on: January 13, 2021

Job Description:

Principal Research Scientist I/II, Neuroinflammation Drug Discovery

  • Cambridge, United States of America
  • Research and Development
  • 2009220 Job Description About AbbVie
    AbbVie's mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women's health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at . Follow @abbvie on Twitter , Facebook , Instagram , YouTube and LinkedIn .

    AbbVie's Foundational Neuroscience Center (FNC) in Cambridge, Massachusetts aims to discover breakthrough treatments for Alzheimer's, Parkinson's, and other neurodegenerative diseases, by conducting in-depth research into fundamental pathological mechanisms, and targeting those mechanisms with world-leading small molecule and biologic drug discovery capabilities. The neuroinflammation group seeks an experienced scientist to conduct and lead target validation and drug discovery projects at its Cambridge, Massachusetts site. Our mission is to produce novel drug candidates that modulate microglial biology in neurodegenerative diseases by targeting mechanisms that emerge from in house-generated single cell transcriptional profiling data and other insights. The successful candidate will bring a deep understanding of mechanisms of neuroinflammation, particularly microglial biology, and a strong record of accomplishment in drug discovery research, in a multidisciplinary environment. This is a "hands on" position with both leadership and bench research responsibilities.
    Key Responsibilities
    • Lead and contribute to target identification and validation research, specifically in the role of neuroinflammation in neurodegenerative diseases. Lead and contribute to drug discovery and advancement research.
    • Stay abreast of, and contribute to, relevant literature.
    • Conduct and oversee the design, execution, and interpretation of novel bench research.
    • Collaborate with colleagues at multiple AbbVie sites to identify and optimize drug leads to produce clinical candidates of outstanding promise.
      • PhD in Neuroscience or related field, with typically 6 - 8+ years of experience, including industrial drug discovery;--or Master's Degree or equivalent with typically 12 - 14+ years of experience; or Bachelor's Degree or equivalent with typically 14 - 16+ years of experience
      • Significant accomplishments in neuroinflammation research and neurodegenerative disease drug discovery, with a strong record of publications and patents
      • Expertise in neuroinflammation and microglial biology
      • Expertise in relevant technologies, such as microglia or hematopoetic iPSC cell culture; genomics, transcriptomics, or proteomics; RNAi or CRISPR screening; flow cytometry; and high content phenotypic screening. Interest in advancing rapidly developing technologies, track record of developing innovative model systems
      • Experience in working in multidisciplinary teams, and in external collaboration
      • Alzheimer's and/or Parkinson's disease experience
        Significant Work Activities
        Yes, 5 % of the Time
        Job Type
        Job Level Code
        Equal Employment Opportunity
        At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.
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Keywords: AbbVie, Inc., Cambridge , Principal Research Scientist I/II, Neuroinflammation Drug Discovery, Other , Cambridge, Massachusetts

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