Scientist, RNA Synthesis

Company: Alnylam Pharmaceuticals
Location: Cambridge
Posted on: November 20, 2020

Job Description:

The RNAi Discovery group at Alnylam is seeking a passionate, creative scientist to join our highly interdisciplinary team focused on the advancement of our RNAi Platform and Lead Development efforts through novel approaches towards a deeper mechanistic/structural understanding of RNAi. The successful candidate will have a strong background in oligonucleotide chemistry/biochemistry through in-depth hands-on experience in the synthesis and chemical/biophysical characterization of oligonucleotides as well as their potential biological applications. Summary of Key Responsibilities Design and execute the automated synthesis, purification, and analysis of siRNAs with various chemistries and scales using state-of-the-art instrumentation platforms Improve and/or develop new processes to expand upon current capabilities Working closely with internal platform teams, identify and develop a vast array of targeting ligands and receptor-ligand pairs, and subsequently execute various bioconjugation strategies for the efficient delivery of siRNA conjugates Troubleshoot and perform routine maintenance on critical instrumentation such as automated synthesis platforms, HPLC, and liquid handling robots Work closely with members across various sub teams within RNAi discovery Analyze, organize, and present data at internal and external meetings Qualifications PhD in Chemistry, Biochemistry, or related discipline with 0-3 years post-degree experience in an industrial or academic setting Strong experience in solid-phase synthesis techniques (prior experience in RNA/DNA synthesis, peptide synthesis, oligosaccharide synthesis is preferred) is required Strong experience in bioconjugation techniques and knowledge in receptor-mediated deliver strategies is preferred Strong laboratory skills and experience with analytical instrumentation such as HPLC, LC-MS, etc. with the ability to analyze, interpret, and clearly present data The ability to apply his/her knowledge to a new area of study as well as to thrive in a highly interdisciplinary team environment with excellent oral and written communication skills Great team-player with a high degree of flexibility and motivation in a fast-paced work environment

Keywords: Alnylam Pharmaceuticals, Cambridge , Scientist, RNA Synthesis, Other , Cambridge, Massachusetts