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Sr. Associate Scientist, Discovery Research

Company: Codiak BioSciences
Location: Cambridge
Posted on: October 8, 2020

Job Description:

Codiak is seeking an experienced senior associate scientist to join our growing Discovery Research organization and contribute to the development of the company's innovative exosome engineering platform. The successful candidate will help advance efforts toward the discovery and optimization of exosome-based therapeutics with the goal of delivering medicines to patients with significant unmet medical need. The position will afford the qualified candidate the opportunity to work alongside a highly dynamic and collaborative team to develop an entirely new therapeutic modality. Essential functions and responsibilities:

  • Support cutting-edge cellular/protein engineering technologies and structural biology principles to further expand our platform approach for creating therapeutic exosomes;
  • Produce, purify, and characterize engineered exosomes from conditioned cell culture medium;
  • Execute biochemical and cell-based assays to validate target and pathway engagement of therapeutic candidates;
  • Express and purify recombinant proteins, including antibodies, enzymes, and fusion proteins, at the milligram scale to support internal and external programs;
  • Cultivate and maintain an in-depth knowledge of exosome biology and engineering;
  • Actively participate in project teams, contribute to technical reports, patent applications, and regulatory filings;
  • Rigorously document research methods and results and effectively communicate findings to the organization at internal meetings..

    Education requirements:
    • BS or equivalent degree in biology, biochemistry, bioengineering, molecular biology or similar discipline with 5+ years of relevant laboratory research experience, in industry preferred;
    • MS or equivalent in a similar discipline with 3+ year of relevant research experience, in industry preferred.Skills and expertise:
      • Passionate about scientific discovery, self-motivated, and eager to learn new skills and contribute to the success of the organization;
      • Excellent organization and communication skills, the ability to collaborate effectively, and an enthusiasm for problem solving;
      • Capability to design and execute thoughtful experiments, troubleshoot, and implement innovative solutions with minimal supervision;
      • Experience with molecular biology techniques, including bacterial culture, plasmid preparation, PCR, restriction digestion, Gibson Assembly, and qPCR;
      • Hands-on experience with mammalian adherent and suspension-adapted cell culture and transfection;
      • Experience with recombinant protein production and purification via IEX, SEC, and affinity chromatography;
      • Experience with protein and cellular characterization methods including ELISA, SDS-PAGE, BCA, western blotting, flow cytometry, microscopy, and ligand binding assays. PI124496830

Keywords: Codiak BioSciences, Cambridge , Sr. Associate Scientist, Discovery Research, Other , Cambridge, Massachusetts

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