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Scientist / Principal Scientist

Company: Amazon Workforce Staffing
Location: Cambridge
Posted on: September 17, 2020

Job Description:

Senior Scientist / Principal Scientist, Natural Product Chemistry Company: LifeMine

Location: Cambridge

Posted on: September 12, 2020

Job Description:

Senior Scientist / Principal Scientist, Natural ProductChemistry LifeMine Therapeutics, Inc. is the firstbiotechnology company exploiting the unique ability of fungi toproduce powerful drugs optimized through billions of years ofevolution, with the overall mission of discovering and deployingnew molecules for the treatment of intractable human diseases. Thecompany is using genomic sequencing, advanced bioinformaticsincluding artificial intelligence, and state-of-the-art syntheticbiology to search the fungal biosphere for drug candidates thatsolve biological problems previously thought to be intractable, andto provide these breakthrough drugs to patients in serious need.With operations in Cambridge, Massachusetts, and Manhattan, NewYork, LifeMine brings a revolutionary scientific approach to acompelling medical mission.

Job Summary

We are seeking a Senior Scientist / Principal Scientist for ourCambridge site with deep expertise in metabolite profiling andnatural product isolation / structure determination strategies tolead a portion of our discovery efforts. This individual shouldhave a demonstrable track record of having isolated complex naturalproducts and elucidated their structures via state-of-the-arttechniques and data interpretation including mass spectroscopic(MS) fragmentation patterns and 1- and 2D nuclear magneticresonance (NMR) data. Substantial hands-on experience withhigh-resolution MS instruments and liquid chromatography (LC)systems is a must. The successful candidate will be highlymotivated and creative, will thrive in a nimble, fast-paced, andperformance-oriented environment, and be able to inspire and leadteams in a matrix reporting environment.

Job Responsibilities

Lead a matrixed team in the acquisition and interpretation ofMS/MS data, particularly fragmentation patterns, to identify andcharacterize complex natural products expressed by fungi.

Develop LC-MS/MS methods for quantitation of secondarymetabolites from fungal extracts.

Develop methods for extractions, and isolation and purificationof natural products from fermentation cultures at analytical andpreparative scale.

Analyze/interpret NMR data from 1D and 2D homo- andheteronuclear to elucidate three-dimensional structures includingrelative stereochemistry.

Ability to perform semi-synthesis and derivatization of naturalproducts to assist with structure elucidation and SAR studies wouldbe a plus.

Evaluate new technologies for metabolite profiling andcharacterization.

Maintain chromatography and mass spectrometry instrumentationand associated analytical software.

Build and maintain strong working relationships with fellowcolleagues within and across functional areas.

Deliver high-quality results, interpretation and reports toDiscovery project teams and other R&D fora.

Job Requirements

PhD in Natural Product Chemistry or related Chemistry field ofstudy.

At least 5 years of industry experience in natural productsdiscovery.

Experience with chromatography and MS method development, strongfamiliarity and aptitude with LC and MS instrumentation includingautomation, and experience in mass spectrometry data analysis andsoftware including automated and manual interpretation of MS/MSfragmentation data.

Ability to rapidly distinguish known from novel naturalproducts, and assignment of chemotype and substituents, based onUV-Vis/MS spectral data (dereplication).

A working knowledge of natural product biosynthetic pathways forpolyketides and non-ribosomal peptides.

Expertise in the set-up and use of 1D and 2D NMR experiments forstructural elucidation and characterization of metabolites.

Knowledge of multiple types of analytical and chromatographicseparation techniques, e.g. RP-HPLC, HILIC, SAEX, SEC, SPE andSFC.

Strong computer skills and experience with software drivenmetabolite profiling (Agilent MassHunter, Waters MassLynx andThermo Scientific Xcalibur).

Excellent written and verbal communication skills.

A record of publishing leading scientific papers in bothspecialized and general-audience journals is a plus.

Demonstrated ability to lead and inspire a matrixed team towardshared goals.

A sense of adventure and excitement to build a new drugdiscovery paradigm.

Excellent interpersonal skills working in a collaborativeenvironment and a strong orientation toward, and commitment to,cross-functional collaborations across multiple diverse programs todeliver key results aimed at advancing drug discovery.

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If your discipline is not listed above, please specifybelow:

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Keywords: LifeMine, Cambridge , Senior Scientist / Principal Scientist, Natural Product Chemistry, Other , Cambridge, Massachusetts

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