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Principal Scientist

Company: Amazon Workforce Staffing
Location: Cambridge
Posted on: September 17, 2020

Job Description:

Company: AISES

Location: Cambridge

Posted on: September 12, 2020

Job Description:

Principal Scientist, Downstream Process Development

SB Principal Scientist, Downstream Process Development SolidBiosciences is an exciting and growing company of 80+ employees whoare recognized for being innovative risk-takers. We are fiercelydedicated to saving patients' lives, but just as passionate abouthaving a positive, employee fulfilled culture.

We have built a very collaborative group of high achieving,innovative and passionate professionals. This is a highlyentrepreneurial environment where your success is determined basedon your contribution, not your title. You must be able to thrive inan autonomous environment and be proactive in your approach. Wehire for culture, not only technical skill. If this resonates withyou, please read on!

Solid Biosciences is a life science company focused solely onfinding treatments, and one day a cure, for Duchenne musculardystrophy (DMD). We aim to be the center of excellence across theentire disease spectrum, serving as a catalyst to bring togetherthose with expertise in science, technology and care, and drivingforward a pipeline of treatment candidates that have life-changingpotential. Disease-focused and founded by a family directlyimpacted by DMD, our mandate is simple yet comprehensive – attackthe roots of the disease and improve daily life for patients.

Key Competencies for Success:

Leadership/Teamwork: Balances team and individualresponsibilities; Gives and welcomes feedback; Contributes tobuilding a positive team spirit; Puts success of team above owninterests; Supports everyone's efforts to succeed.

Quality Results: Demonstrates accuracy and thoroughness; Looksfor ways to improve and promote quality; Applies feedback toimprove performance; Monitors own work to ensure quality.

Adaptability: Able to adapt to changes in the work environment;Manages competing demands; Changes approach or method to best fitthe situation; Able to deal with frequent change, delays orunexpected events.

Ethics: Treats people with respect; Inspires the trust ofothers; Works with integrity and ethically; Upholds organizationalvalues.

Requirements

Summary of role: Solid Biosciences is seeking an experiencedPrincipal Scientist to join our Process Development team andcontribute to the development of our downstream viral vectormanufacturing processes. This individual will join a dynamic andmotivated team to develop and characterize unit operations insupport of a mid to late stage viral vector program, as well astech transfer of the process to the clinical/commercialmanufacturing team.

The successful candidate will be responsible for leading a teamof scientists and engineers on the design and execution ofexperiments supporting troubleshooting, development,characterization, scale-up, and transfer of the downstreammanufacturing processes. They will also be responsible forevaluation and implementation of new and existing technology.

What's in it for you?

Opportunity to:

Oversight, scheduling, planning and reviewing of viral vectorprocess development and tech transfer experiments in the PD labrelated to all downstream processes and in-process analytics, toinclude process optimization and problem-solving processes andequipment

Lead a team of scientists and engineers focused on developmentand optimization of viral vector purifications processes

Identify, evaluate, and implement new and existing technologiesto improve process efficiency, control, and understanding

Coordinates with Upstream PD and analytical development onmultiple projects simultaneously

Apply DOE and other advanced statistical techniques to designexperiments related to process development, characterization, andscale-up

Authoring of high-quality documents, including technicalreports, presentations, SOPs, experimental protocols, andregulatory filings

Develops and mentor direct reports through challengingassignments and providing constructive feedback, goal setting andmonitoring performance on a routine and ensuring that overallproject goals are on track

Self-motivated, accountable, inquisitive, with excellentorganizational and communication skills

Flexibility to switch between projects

Ability to lead/manage junior team members

What we need from you:

Ph.D. in Chemical Engineering or related field and 6+ years ofexperience, Master’s or a Bachelor’s degree in the same field with10+ years of experience in downstream process development

Strong scientific skills and process development experienceworking with gene therapy products

Proven expertise in all downstream purification conceptsincluding chromatographic separation, centrifugation, filtration,and viral inactivation/removal

Excellent technical, organizational, interpersonal,collaborative, and verbal/written communication skills - includingexcellent presentation skills and the ability to communicate withemployees at all levels including senior management

Strong understanding of GxPs, process characterization, andtechnology transfer

Ability to manage, analyze, and interpret complex experimentaldata

Ability to apply engineering fundamentals to process design andscale-up

Ability to apply statistical tools for process monitoring,experimental design, and data analysis

Travel Commitment:

Some travel may be required

Job Information

Job ID: 54026085

Location:

Cambridge, Massachusetts, United States

Position Title: Principal Scientist, Downstream ProcessDevelopment

Company Name: Solid Bioscience

Job Function: Scientist

Job Duration: Indefinite

Min Education: BA/BS/Undergraduate

Min Experience: Over 10 Years

Required Travel: 0-10%

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Keywords: Amazon Workforce Staffing, Cambridge , Principal Scientist, Other , Cambridge, Massachusetts

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