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Senior / Principal Scientist, CRISPR Protein Development

Company: Colorado School of Mines Alumni
Location: Cambridge
Posted on: September 17, 2020

Job Description:

Colorado School of Mines Alumni Job Center We believe the solutions to some of the greatest challenges facing humanity are rooted in nature. By harnessing the power of nature to solve complex global problems, we are mining previously unexplored scientific territory. We have built a next generation biodiscovery platform to uncover novel CRISPR enzymes and systems that can power transformative applications across a range of industries. Our actions as a company and as individuals are designed to maximize our impact on problems facing humanity.

Position Overview:

CRISPR is a game changer in genome editing and gene therapy. We have discovered a number of novel CRISPR systems that hold promises in therapeutics and diagnostics. We are looking for someone who will play a critical role in translating these discoveries for human health and environmental sustainability.

Job Responsibilities:

Establish robust expression and process development procedures for Arbor lead nucleases

Establishing appropriate QC specifications and analytical methods to evaluate / monitor protein quality and stability

Identify and validate conditions for RNP complexation and mammalian cellular delivery for optimum performance

Conduct formulation screening and analytical assessment to identify suitable protein / RNP formulations

Scale production processes as appropriate to support internal and external protein / RNP needs

Manage internal protein production, QC testing, inventory tracking, as well as internal and external materials transfers

Coordinate with Application Development team to facilitate cross-training and materials handoffs of Arbor lead nuclease RNPs

Author, revise, and update SOPs as necessary

Mentor, train, and coach junior team members

Manage relationships with CROs to support protein Process Development and production

Requirements

Job Requirements:

PhD in Biochemistry or a similar discipline or related experience

5+ years of relevant industry experience

Deep knowledge of CRISPR gene editing technologies with strong preference for RNP-based delivery modality

Established ability to develop, optimize, and execute microbial protein expression and purification workflows to produce material suitable for testing in mammalian primary cells (Pharma / Biotech Process Development is a plus)

Proficiency with biochemical (enzymatic activity, protein: nucleic acid interactions) and bioanalytical (DLS, DSF, SEC-MALS) methods to evaluate protein quality/stability and determine optimal protein/RNP formulations

Experience with mammalian tissue culture (cell line maintenance, transfection / nucleofection, genomic DNA extraction)

Demonstrated success in leading projects and mentoring junior team members

Ability to make recommendations to effectively resolve problems or issues, by using sound judgment that is consistent with business standards, practices, policies, procedures, and regulations

Ability to think strategically and execute tactically

Preferred Experience:

Familiarity with cGMP regulations, FDA/EMA guidance for protein biologics

Previous experience supporting early process development for protein biologics

Prior experience establishing and managing relationships with CROs

Arbor Biotechnologies is an equal opportunity employer. We recruit, employ, train, compensate, and promote without regard to race, religion, creed, national origin, age, gender, sexual orientation, sexual identity, marital status, military or veteran status, disability, genetic information, or any other category protected by applicable federal, state or local law.

Arbor Biotechnologies does not accept unsolicited agency resumes. Staffing agencies should not send resumes to our HR team or to any Arbor Bio employees. Arbor Bio is not responsible for any fees related to unsolicited resumes from staffing agencies.

Job Information

Job ID: 54627127

Location:

CAMBRIDGE, Massachusetts, United States

Arbor Biotechnologies is a venture-backed startup based in Cambridge, MA, composed of a small team of scientists and engineers pushing the boundaries of discovery at the intersection of computer science and biotechnology. Using our diverse backgrounds ranging from machine learning to genome engineering to protein biochemistry, we are building a platform to uncover and characterize nature’s inventions on an unprecedented scale to generate impactful applications in human health and sustainability. We seek highly-motivated ...

Massachusetts Institute...

Cambridge, MA, United States

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In Vivo Pharmacology Research Scientist

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Research Scientist/ Senior Scientist, Novartis...

Cambrudge, 553096, United States

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Senior/Executive Director, Biologics Development

Colorado School of Mines Golden, CO 80402

Keywords: Colorado School of Mines Alumni, Cambridge , Senior / Principal Scientist, CRISPR Protein Development, Other , Cambridge, Massachusetts

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