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Associate Director

Company: Amazon Workforce Staffing
Location: Cambridge
Posted on: September 17, 2020

Job Description:

Associate Director - Innovative Gene Therapies and AAV Vector Core Company: HCPro

Location: Cambridge

Posted on: September 12, 2020

Job Description:

Associate Director Innovative Gene Therapies and AAV VectorCore, 299642BR

N Associate Director Innovative Gene Therapies and AAV VectorCore, 299642BR Novartis Institutes for BioMedical Research(NIBR)

900+ clinical trials! That is why gene therapies aretransforming the practice of medicine. As an Associate Director ofGene Therapies, you will have an opportunity to join the NIBRBiologics Center (NBC) and be at the cutting edge, leading thedevelopment of innovative medicines that can improve lives ofpatients.

NBC builds the biologics pipeline in collaboration with NIBRDisease Areas and Platforms via a breadth of technologies fordiscovery of antibody, protein and gene therapy-basedtherapeutics.

We are seeking a highly motivated scientist and leaderspecialized in viral and non-viral gene therapies with an emphasison AAV to join the Biotherapeutic Engineering and Gene Therapy(BEGT) group within NBC in Cambridge, Massachusetts. The BEGT groupdrives a diverse portfolio of modalities including therapeuticproteins, multi-specific antibodies, CAR-T, RNA therapeutics andAAV. Through innovative and rational protein design as well as celland viral engineering, the BEGT group works collaboratively withDisease area groups to broaden the use of biologics intotherapeutic applications where conventional antibodies havelimitations.

Your key responsibilities are, but not limited to:

Lead a team of highly talented scientists responsible to driveAAV innovation to patients.

Evaluation and implementation of approaches for regulatable geneexpression/knockdown, optimized tissue-specific promotors andredirected tropism.

Management of NBC’s AAV viral vector core for production of avariety of AAV serotypes at research scale (discovery throughNHP).

Bridge protein engineering expertise, conjugation and capsidengineering to bring the next generation of cell specific genedelivery platforms into the pipeline.

Functional characterization of novel constructs via in vitrocellular assays for selectivity and activity.

Interface with downstream development colleagues to bring leadcandidates towards full developmment.

Offer innovative approaches to scientific questions andtroubleshooting efforts

Identify Disease Area’s unmet needs and collaborate for a noveltherapeutic solution

Requirements

What you will bring to the role:

Expertise in AAV therapeutic design, production andcharacterization and delivery is essential.

Prior experience with lentiviral mediated gene therapy andnonviral gene therapies would be a plus.

Knowledge in molecular biology, protein engineering and capsidengineering approaches to optimize expression, function andspecificity of the transgene.

Highly collaborative spirit inside and outside of department toadvance programs to clinic; good communication skills, creativity,and multi-tasking in a fast-paced environment

Knowledge in application of gene therapy to biology in the areasof oncology, immunology, neuroscience, muscular skeletal disordersor opthamology.

PhD with more than 10 years relevant experience in AAV mediatedgene delivery.

Experience managing and mentoring direct reports including PhDlevel scientists.

Job Information

Job ID: 54385019

Location:

Cambridge, Massachusetts, United States

Position Title: Associate Director Innovative Gene Therapies andAAV Vector Core, 299642BR

Company Name: Novartis Institutes for BioMedical Research(NIBR)

Job Function: Scientist

Job Type: Full-Time

Job Duration: Indefinite

Min Education: Ph.D.

Min Experience: Over 10 Years

Required Travel: 0-10%

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