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Principal Scientist

Company: Amazon Workforce Staffing
Location: Cambridge
Posted on: September 17, 2020

Job Description:

Company: Astellas

Location: Cambridge

Posted on: September 12, 2020

Job Description:

National Postdoctoral Association Career Center Developinginnovative therapies is one of the most challenging, most essentialand personally rewarding fields in science. This is the mostexciting time to be a part of Astellas, a company with a uniquelycollaborative and patient-focused culture.

There's something special about working at Astellas. It'sreflected in our focus on the people we serve, the way we treateach other and the results we achieve together as a company.

Astellas is announcing a Principal Scientist opportunity attheir new affiliate Mitobridge in Cambridge, MA.

At Mitobridge, we are passionate about developing noveltherapeutics that improve mitochondrial function to treatdevastating human diseases. Mitochondrial dysfunction isincreasingly linked to disease pathophysiologies interdicting atthe level of mitochondrial function can be disease altering. We areseeking a motivated and energetic Principal Scientist to join ourteams and advance programs.

Purpose:

The role of the Principal Scientist is to build and overseepreclinical drug development programs in the CNS field from conceptthrough IND submission. The candidate will assume responsibilityfor the design and execution of all non-clinical work up to andincluding the IND-enabling studies such as assay development, invitro and in vivo pharmacology and toxicology studies.

The successful candidate will be an outstanding scientist withCNS pathophysiology expertise and experience in overseeing thedesign, execution and interpretation of non-clinical pharmacologyand toxicology studies. Experience preparing successful INDsubmissions in a pathophysiology/biology driven approach isessential. S/he will be expected to develop and maintain strongcollaborations and relations with external experts in thenon-clinical and clinical CNS field.

Participate and/or lead multiple CNS focused projects withindiscovery, provide scientific expertise, guidance and strategy tosuccessfully bringing programs to IND submission.

Propose, plan and manage and execute studies to characterize thecompany's drug candidates and their mechanism of action to moveprograms from discovery to clinical development in CNSdisorders.

Plan and implement translational research includinginvestigation of pharmacodynamics markers of target engagement,markers predictive of or correlating with clinical efficacy anddisease biology

Responsible for preparation of study reports, regulatory filingsand project presentations

Manage a portfolio of targets related to CNS disorders, overseestrategic execution of discovery research and preclinicalactivities to enable robust, timely and compliant IND submissionswith clear development paths

Provide expert level guidance in designing and implementing cellbiology, in vivo pharmacology and biomarker related studies

Interface with external partners, clinical and academiccollaborators, and CROs

Provide high-level updates and advice to senior management,including evaluation of data and their potential impact on drugprograms and clinical/regulatory strategy

Lead (directly & indirectly through projects) the CNS biologyaspects of ongoing and future projects. Provide developmentopportunities and mentoring to direct reports.

Keep abreast of emerging developments regarding research anddevelopment in the fields of CNS disorders, emerging new biologyand new modalities that could facilitate identification of newtargets or development of new therapeutics

Requirements

PhD. with 8+ years highly relevant neurobiology experience, MSwith 10+, BS with 15+

5+ years of experience in a biopharmaceutical setting

Direct hands-on experience co-leading drug discovery projectsfrom target validation to IND-enabling studies in the CNS field

Demonstrated creativity and novel approaches to solvingscientific problems

Knowledge of preclinical and clinical biomarker discovery anddevelopment

Good understanding of preclinical PK/PD/efficacy relationshipsand their translation to the clinic

Strong leadership, interpersonal and communication skills withan enthusiasm for participating in a fast-paced environmentcharacterized by rigorous science and innovative thinking

Demonstrated application of expertise to drug discovery in theCNS therapeutic areas

Significant experience as a team member and/or leadingmulti-disciplinary teams focused on small molecule drugdiscovery

Experience with engaging and managing external efforts withcontract research organizations and academic collaborators

At home in a results-driven, highly accountable environmentwhere you can make a clear impact

A team player and mentor, who listens effectively and invitesresponse and discussion. A collaborator who communicates in anopen, clear, complete, timely and consistent manner

Preferred

Experience in CNS pathophysiology, mitochondrial biology, smallmolecule pharmacology

Experience working within large pharma organizations and/orbiotech/start up environment

Deep understanding and experience of CNS experimental modelsfrom rodents to non human primates and human disease samples

#LI-JA1

Equal Opportunity Employer Minorities/Women/ProtectedVeterans/Disabled

Category Research and Development

Job Information

Job ID: 54399890

Location:

Cambridge, Massachusetts, United States

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Keywords: Astellas, Cambridge , Principal Scientist, Neuroscience, Other , Cambridge, Massachusetts

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