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Associate Scientific Director, Clinical Biomarker Scientist

Company: Amazon Workforce Staffing
Location: Cambridge
Posted on: September 17, 2020

Job Description:

Associate Scientific Director, Clinical Biomarker Scientist Company: Takeda Pharmaceuticals International GmbH

Location: Cambridge

Posted on: September 12, 2020

Job Description:

We're looking for a candidate to fill this position in anexciting company.

The clinical biomarker department at company is seeking anoutstanding scientist to develop novel pharmacodynamic anddiagnostic biomarkers that will impact clinical developmentparadigms and bring value to patients. The candidate will overseedifferent therapeutic modalities across Oncology, Neuroscience,Gastroenterology, Immuno-oncology, and Rare Diseases.

The successful candidate will have a strong and compellingvision for driving biomarker science, its impact on drugdevelopment decisions, and supporting the development andcommercial pipeline. With an increase in the therapeutic areas,complexity, diversity and number of molecules/modalities in ourportfolio, we expect the leader to provide scientific and drugdevelopment expertise in all aspects of biomarker sciences,including a deep understanding of disease biology, drugpharmacology, molecular pathways, clinical endpoints, clinicaltrial designs and diagnostics. An additional requirement is theability to develop and leverage cutting-edge technologies that cansignificantly impact clinical drug development decisions.

The Associate Scientific Director will also be a strong mentorand coach to the group. Success in this role will be evaluated bythe ability to influence and inspire scientists in theorganisation, and maintain a culture that encourages innovation,scientific rigor, and growth opportunities.

Build innovative cross-translational strategies for thedevelopment and evaluation of relationships between clinicalbiomarkers (e.g., disease monitoring, pharmacodynamic/response,surrogate, safety) and PK/PD metrics including target occupancy,engagement, and physiological response in target tissue directlylinked to pathophysiology.

A PhD in a life scientific discipline with a minimum of 10 yearsor MS with 14+ years and 5+ years of industry and managerialexperience required.

A productive track record of sustained, significant scientificcontributions as demonstrated by publications, patents andpresentations

Extensive drug development experience preferably advancingseveral molecules from phase I to approval and supportingpost-marketing/commercial activities. Experience in development ofcell/gene-based therapies is desirable but not required.

Strong scientific background and experience with clinicalbioanalytical assay development and validation. Subject matterexpert in analytical platforms such as flow/mass cytometry,next-generation sequencing, immunoassays, companion diagnostics,etc.

Expert executive communication skills; ability to influence andinspire, preferably experienced in navigating and influencinglarge, highly complex, global matrixed environments with andwithout authority.

Broad and strong network in the industry, biotech, CROcommunities, and health authorities.

Keywords: Takeda Pharmaceuticals International GmbH, Cambridge , Associate Scientific Director, Clinical Biomarker Scientist, Other , Cambridge, Massachusetts

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Keywords: Amazon Workforce Staffing, Cambridge , Associate Scientific Director, Clinical Biomarker Scientist, Other , Cambridge, Massachusetts

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