Revitope Oncology (www.revitope.com) is an early stage
biotechnology company located in the heart of Cambridge,
Massachusetts, with the vision to drive the development of
next-generation immunotherapies to treat solid and liquid tumors.
Immunotherapies are redefining how cancer is treated and are
beginning to show unprecedented deep and durable responses in
multiple tumor types. In particular, redirecting T cells to tumors
is a successful strategy for immunotherapy but to date severe
toxicities arising from targeting of healthy tissues is limiting
their full potential.
Revitope is developing a new class of T-cell engaging
immunotherapies designed to focus immunological activation
specifically to the cancer cell surface while avoiding unwanted
toxicity in healthy tissues. Our approach also expands antigenic
targeting space through exploiting two antigens co-expressed on
tumor cells. Revitope’s proprietary technology platform and
enabling skill base lends itself to partnering opportunities as
well as to driving internal programs towards the clinic. Revitope
has already signed a significant collaboration and is actively
engaged in discussions with others.
We are now looking to add a highly motivated and enthusiastic
Senior Scientist to join our growing cross-functional team. This
individual will develop new in vitro assays to characterize
Revitope platform as well as therapeutics advancing in the
pipeline. This is a unique opportunity to develop novel preclinical
assays and adapt/evolve key assays to formats suitable for clinical
analysis, while contributing to the development of new biologics
drugs for cancer immunotherapy in a highly collegial start-up
Key Responsibilities Act as company expert in the areas of novel
assay development and transition of assays to formats suitable for
clinical assessment; provide valuable insight into the global
understanding of the Revitope platform pre-clinically as well as
providing critical assays for decision making clinically.
Guide design of novel assays needed for platform development and
In concert with Biology team devise strategies for evaluating
the expression of candidate targets, assessing toxicity risk, and
informing final target selection
Lead small group of in-house research associates while
maintaining a strong hands-on presence in the laboratory.
Train and/or oversee research associates to develop novel assays
including assay design and conduct, data collection, review and
Work collaboratively and seamlessly with in vitro, in vivo and
protein sciences colleagues as well as external experts to
effectively investigate new candidate molecules.
Effectively document experimental analyses and communicate
within the organization and externally.
Participate in strategic and priority setting discussions with
senior leadership and project teams and design appropriate assays
and plans in line with company goals and timelines.
Review and ensure the quality of scientific data to meet
Author peer-reviewed publications, technical and regulatory
documents to support advancement of therapeutics to clinical
Required Qualifications PhD or equivalent in biological
sciences, immunology, oncology, pharmacology or a related
discipline with a minimum of 5-8 years in vitro experience in
biotech/pharma; background in the area of T cell redirection and/or
CART therapeutics preferred.
Leader with strong track record in the development of novel
assays including experimental design, standardization, data
analysis and interpretation, statistics and transformation of
preclinical assays to formats suitable for clinical analyses.
Highly technically proficient in broad array of in vitro assay
approaches and techniques for investigating effects of
antibody-based therapeutics on cells.
Experience in diverse approaches to studying protein expression
(flow cytometry, immunofluorescence, immunohistochemistry,
proteomics) highly preferred.
Experience in protease biology a plus.
Demonstrated ability to interpret data from single experiments
and integrate data from diverse experiments to draw clear
Highly motivated strong team player with experience leading
in-house projects as well as studies conducted at academic
Experience leading and managing direct or matrixed reports and
demonstrated ability to develop young scientists.
Ability to manage timelines and set priorities consistent with
goals for advancing therapeutics.
Possession of strong communication skills, both written and
verbal, to clearly convey complex strategies and scientific data
and tailor messaging to diverse audiences
Ability to work collaboratively, inclusively, ethically and
thrive in the fast paced and changing environment of a small
What We Offer
This is a unique opportunity to be among the first employees at
a fast-paced, rapidly growing biotech startup with a bold vision.
As an early employee, you will have a direct influence on the
science, opportunities to gain new skills and be joining an
ambitious, innovative, and collaborative team.
Revitope is deeply committed to diversity, equality, and
inclusion in all of its practices, especially when it comes to
growing our team. We hope to continue to build a company whose
culture promotes inclusion and embraces how rewarding it is to work
with individuals from all walks of life.