The Proteomics Group (Carr Lab) at the Broad Institute of MIT
and Harvard is looking for highly motivated research associates to
develop and apply state-of-the art proteomics technology to address
compelling questions in biology, chemistry and clinical medicine.
The specific research areas of immediate interest that this
scientist could drive include:
proteogenomic studies of a wide range of cancers
detailed studies of cellular signaling networks related to
protein phosphorylation, ubiquitylation or acetylation
unveiling the targets of drugs or identifying protein
interactors through chemical proteomics technologies and affinity
developing biological understanding of response and resistance
developing and optimizing new, broadly enabling proteomic
technologies including targeted, quantitative MS assay development
for proteins and modifications of high biological or clinical
Successful candidates will work in many of these areas together
with an interdisciplinary team of clinicians, biologists,
computational and proteomics scientists to deeply characterize and
understand the proteomes of tumor-derived material, cells and
Qualifications: Candidates must have:
Bachelor’s degree in Chemistry or Biochemistry and 5+ years of
experience in a research laboratory, or a Master’s degree in
analytical chemistry or biochemistry and 4+ years of
3+ years of experience in MS based proteomics, significant
experience with MS, HPLC, peptide and protein separation.
high productivity, evidenced by high-quality collaborative
science and research publications in peer reviewed journals on
which they are named co-authors
excellent verbal and written communication skills
Hands on skills and knowledge in one or more of the following
areas will be considered an advantage:
Knowledge of various scientific databases and experience with
publishing and presenting experimental results highly
Experience in statistical and/or computational analysis of
posttranslational modification analysis such as phosphorylation,
cell biology/ biochemical methods to understand protein
The Broad Institute is a world-leading non-profit research
organization dedicated to realizing the promise of the post-genomic
era for human benefit. Located in Cambridge, MA with strong ties to
MIT, Harvard, and world class Boston hospitals, the Broad Institute
brings together scientists of diverse backgrounds to solve critical
problems in biology and medicine in an interdisciplinary manner.
The Broad Institute, and the embedded Proteomics Group
(www.broadinstitute.org/proteomics), have an outstanding
track-record in training the next generation of research scientists
and in developing and applying proteomic technologies critical to
address important questions in biology and medicine. We collaborate
with top-level researchers throughout the world, and results of
these studies and our technology developments are published in
Interested scientists are encouraged to apply on-line at the
Broad Website. Inquiries can also be addressed to Steve Carr,
Director of Proteomics, Broad Institute (email@example.com or
Works with senior staff to set experimental strategy, project
goals and timelines and works directly with collaborator teams to
drive projects toward successful completion. Helps define
Carries out detailed LC- and nanoLC-MS/MS analyses of complex,
biologically derived protein, peptide and small molecule mixtures,
including PTMs. Consults scientific literature and collaborates
with other researchers from the scientific community as needed.
Tracks and compiles results.
Helps develop and optimize new technologies and protocols;
assists with the training of lab personnel on new
Utilizes laboratory automation instrumentation to execute
established proteomic workflows.
Helps to produce and isolates samples for proteomics studies
using cell culture techniques, immunoprecipitation, subcellular
fractionation methods and protein sample preparation from tissues
Utilizes other protein biochemistry and proteomic techniques
such as western blotting, multidimensional chromatography and
in-gel digestion to meet project and research goals.
Operates and maintains one or more LC-mass spectrometers (Thermo
QExactive-series, Thermo Lumos-series, Bruker TIMS-Tof) and HPLC
systems for peptide separation and analysis.
Helps ensure that project support, such as software, instrument
spares, lab reagents, etc. are in place in accordance with project
Prepares detailed technical documents describing procedures and
results. Independently prepares posters and assists in preparation
of reports and manuscripts for meetings and peer-reviewed
literature. Will assist supervisory scientists and collaborators
with writing and editing as needed.
Orders supplies, helps to maintain stock of common expendables
and reagents for Proteomics lab
The Broad Institute will not offer Visa sponsorship for this
All qualified applicants will receive consideration for
employment without regard to race, color, religion, sex, sexual
orientation, gender identity, national origin, disability or
protected veteran status.
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