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Senior Scientist, Medicinal Chemistry

Company: Civetta Therapeutics
Location: Cambridge
Posted on: September 15, 2020

Job Description:

Location: US-MA-CambridgeID: 2# of Openings : 1Category: Research & DevelopmentAddress: 10 Wilson Road

Overview

Civetta Therapeutics is recently founded small molecule discovery company located in the biotechnology hub of Cambridge (MA), backed by Deerfield management and spun out of Dana-Farber Cancer Institute and the Broad Institute. We are advancing the vision of our founders, Drs. William Sellers (DFCI/Broad) and Eric Fischer (DFCI), to develop new medicines, targeting beta-propeller proteins to treat a range of diseases including cancer. We are building a world-class team of researchers to deliver on this promise. If you are a talented life sciences professional who brings energy, passion and talent, we invite you to apply to join our exciting and growing team.

Civetta is seeking to hire a Senior Scientist in Medicinal Chemistry to contribute to our targeted drug discovery programs and the development of our beta-propeller platform. We are building a drug discovery platform to enable basic research and deliver clinical candidates on multiple promising targets. We are seeking a medicinal chemist with significant pharmaceutical industry experience to join our multi-disciplinary team to aid and support all our target identification, hit optimization and clinical candidate discovery efforts.

Responsibilities

Responsibilities:

  • Medicinal chemistry support for specific drug discovery programs including intellectual contributions to all stages of drug discovery from compound design & evaluation, IP protection through to development strategies for the molecule.
  • Contribute to the development of our platform by enhancing our medicinal chemistry capabilities and resources.
  • Management of chemistry CROs to enable company project and platform delivery.
  • Collaborate with chemistry, biochemistry, and biology colleagues to contribute and evaluate progress towards project/platform goals.
  • Prepare reports and presentations for leadership and to participate in internal/external meetings.

    Qualifications

    Qualifications:

    • PhD in Organic or Medicinal Chemistry with 7+ years of experience in medicinal chemistry in a biotech or pharma setting and a demonstrated track record of contributions to identification of development candidates. BS/MS candidates with an exceptional track record and > 10 years of experience will also be considered.
    • A solid understanding of synthetic methodology, SAR driven compound optimization, use of modelling software and experience in structure-based design are required.
    • Knowledge of ADME/PK assays, enzymology, pharmacology, chemical biology and fragment-based lead discovery will be an advantage.
    • Experience working with/managing synthetic chemistry CROs will also be helpful.
    • Enthusiasm for building internal and external chemistry teams and to mentor junior colleagues desired.
    • As a long-term goal, some laboratory work can be expected.
      Civetta Therapeutics provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to religion, race, creed, color, sex, sexual orientation, alienage or citizenship status, national origin, age, marital status, pregnancy, disability, veteran or military status, predisposing genetic characteristics or any other characteristic protected by applicable federal, state or local law

      #PM18

      #LI-DNI

Keywords: Civetta Therapeutics, Cambridge , Senior Scientist, Medicinal Chemistry, Other , Cambridge, Massachusetts

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