CambridgeRecruiter Since 2001
the smart solution for Cambridge jobs

Senior Director, Process Development

Company: The American College of Radiation Oncology
Location: Cambridge
Posted on: September 14, 2020

Job Description:

Senior Director, Process Development

TCR2 Therapeutics

Cambridge, Massachusetts, United States

8 hours ago

Apply Now

Description

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage immunotherapy company pioneering the development of novel T cell therapies. Our two lead cell product candidates are being studied in Phase 1/2 trials: TC-210, for solid tumors and TC-110 for hematological malignancies. Our research efforts focus on broadening our pipeline with a series of next-generation enhancements that may further improve clinical outcomes. We are headquartered in Cambridge, Massachusetts and have a clinical manufacturing facility in Stevenage, UK.

The position represents a key leadership position within the company and an excellent opportunity for career development in a fast-paced and highly collaborative environment. The individual will work closely with the manufacturing, clinical and discovery teams through all stages of clinical development.

The successful candidate will be expected to play an integral role in the development and translation of the TRuC^TM T cell platform. Specifically, the successful candidate will drive internal innovation and development of lentiviral and T cell manufacturing platforms and manage the technology transfer to GMP facilities as the programs develop. The candidate will be expected to grow and manage a cutting-edge team that will catalyze the growth of the TCR^2 platform.

Responsibilities:

* Manage lentiviral process development for pre-clinical and clinical candidates and optimize manufacturing processes for both in-house and tech transfer needs.

* Lead process development strategy and execution for gene-edited ex-vivo cell therapy products based on TRuC T cells for rapid transition of early-stage candidates into the clinic.

* Partner closely with the research team to guide process development program to ensure a streamlined and feasible product development transition.

* Manage technology transfer strategy, protocol development and establish acceptance specifications for transition to GMP facilities for all CMC activities with ability to travel for in-person and in-plant interactions.

* Provide oversight and technical support to the clinical manufacturing programs.

* Define and build an effective team to oversee process development/transfer and in-house manufacturing oversight through personal leadership, and direct reports.

* Author and review CMC content for IND submissions for clinical trials.

* Collaborate with other departments to identify efficiencies needed to meet critical corporate objectives, encompassing the area of viral vector and engineered T cell manufacturing.

* Define departmental goals and manage experimental programs to align with corporate goals.

* Determine and manage departmental yearly budget.

* Influence through effective communication, respectful challenge, and persuasion across the research organization.

Requirements

Requirements:

* Ph.D. in Cell Biology, Immunology or Virology is preferred.

* A minimum of 10-12 years post-graduate experience in an industrial setting.

* Demonstrated skills in building teams and executing on projects in a timely manner.

* Proven track record in leading pre-clinical stage programs and cross-functional teams through to successful INDs.

* Biotech experience is strongly preferred with a focus on cell and gene therapy, virology or biologics.

* Previous experience with development and manufacture of viral vectors and engineered T cells is strongly preferred.

* Ability to adapt and thrive in a dynamic and entrepreneurial early-stage environment.

* Superior personnel management and organizational skills.

* A scientifically motivated self-starter, capable of independently conceiving, conducting, and critically analyzing his/her own work with minimal supervision.

* A strong presenter and communicator, with the ability to work in a fast-paced and team-oriented environment.

Job Information

* Job ID: 54650032

* Location:

Cambridge, Massachusetts, United States

* Position Title: Senior Director, Process Development

* Company Name: TCR2 Therapeutics

* Job Function: Oncology,

Process Development

* Job Type: Full-Time * Ph.D. in Cell Biology, Immunology or Virology is preferred.

* A minimum of 10-12 years post-graduate experience in an industrial setting.

* Demonstrated skills in building teams and executing on projects in a timely manner.

* Proven track record in leading pre-clinical stage programs and cross-functional teams through to successful INDs.

* Biotech experience is strongly preferred with a focus on cell and gene therapy, virology or biologics.

* Previous experience with development and manufacture of viral vectors and engineered T cells is strongly preferred.

* Ability to adapt and thrive in a dynamic and entrepreneurial early-stage environment.

* Superior personnel management and organizational skills.

* A scientifically motivated self-starter, capable of independently conceiving, conducting, and critically analyzing his/her own work with minimal supervision.

* A strong presenter and communicator, with the ability to work in a fast-paced and team-oriented environment.

Keywords: The American College of Radiation Oncology, Cambridge , Senior Director, Process Development, Other , Cambridge, Massachusetts

Click here to apply!

Didn't find what you're looking for? Search again!

I'm looking for
in category
within


Other Other Jobs


Amazon Workforce Staffing: Amazon Order Filler - Immediate Hire ( Fall River)
Description: Warehouse
Company: Amazon Workforce Staffing
Location: Woonsocket
Posted on: 09/23/2020

Amazon Workforce Staffing: Amazon Warehouse Worker
Description: Warehouse
Company: Amazon Workforce Staffing
Location: Woonsocket
Posted on: 09/23/2020

LNA's 3pm - 11pm
Description: Job Description:Overview Birch Hill Manchester LNA - Per Diem 3pm - 11pm Birch Hill, Manchester NH's only continuing care retirement community offering three levels of care - independent, assisted living (more...)
Company: RiverWoods Retirement Community
Location: Concord
Posted on: 09/23/2020


Amazon Prime Now Shopper (Part-Time) - Earn $15/hr or more
Description: Schedule: Part-Time Regular Salary Earn 15.00/hr or more Amazon remains open as an essential service to serve our communities delivering critical supplies directly to the doorsteps of people who (more...)
Company: Amazon
Location: Woonsocket
Posted on: 09/23/2020

Warehouse Operator - Up to $18.25 per hour
Description: Full-time Warehouse Team Member - 500 sign-on bonus Hourly pay rate Earn 15.75 - 18.75/hr, plus benefits and a 500 sign-on bonus. Limited-Time Opportunity Location: Taunton, MA Job opportunities vary (more...)
Company: Amazon Workforce Staffing
Location: East Providence
Posted on: 09/23/2020

Amazon Warehousing Worker - Earn up to $18.25/hr plus benefits and a $1000sign-on bonus
Description: Seasonal Full-time Warehouse Team Member - 1000 sign-on bonus Hourly pay rate: Earn 15.25 - 18.25/hr, plus benefits and a 1,000 sign-on bonus. Limited-Time Opportunity Location: Milford, (more...)
Company: 8162
Location: Woonsocket
Posted on: 09/23/2020

Transportation SupervisorAmazon Warehouse Assistant - Different Shifts Available
Description: Shifts: Early Morning, Day, Evening Location: Milford, MA Job opportunities vary by location. We update postings daily with open positions. Hourly Pay Rate 15.75/hr - 18.75/hr , plus (more...)
Company: 8162
Location: Woonsocket
Posted on: 09/23/2020

Amazon Workforce Staffing: Amazon Order Filler - Full-Time Night Shifts Available
Description: Warehouse
Company: Amazon Workforce Staffing
Location: East Providence
Posted on: 09/23/2020

Amazon Workforce Staffing: Order Fulfillment Team Member
Description: Warehouse
Company: Amazon Workforce Staffing
Location: East Providence
Posted on: 09/23/2020

Amazon Workforce Staffing: Amazon Picker/Packer - Immediate Hire
Description: Warehouse
Company: Amazon Workforce Staffing
Location: East Providence
Posted on: 09/23/2020

Log In or Create An Account

Get the latest Massachusetts jobs by following @recnetMA on Twitter!

Cambridge RSS job feeds