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Principal Scientist, Immunology Research

Company: TCR2 Therapeutics
Location: Cambridge
Posted on: September 14, 2020

Job Description:

National Postdoctoral Association Career Center Principal Scientist, Immunology Research

TT Principal Scientist, Immunology Research At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage immunotherapy company pioneering the development of novel T cell therapies. Our two lead cell product candidates are being studied in Phase 1/2 trials: TC-210 for solid tumors and TC-110 for hematological malignancies. Our research efforts focus on broadening our pipeline with a series of next-generation enhancements that may further improve clinical outcomes. We are headquartered in Cambridge, Massachusetts and have a clinical manufacturing facility in Stevenage, UK.

TCR² Therapeutics is seeking a talented and highly motivated candidate to lead our in vitro efforts to identify lead TRuC candidates for both hematological and solid tumor targets. The successful candidate will have a profound understanding of T cell biology and the regulation of T cell functions by the tumor microenvironment, with proven track record in leading the efforts to understand the mechanism of action of engineered T cells and improve the function of T cells. She/he will guide and manage a collaborative cross-functional team in the design and implementation of studies to elucidate TRuC T cell functions and to inform lead nomination and go/no-go decision on programs across early discovery, late discovery and pre-IND stages.

Responsibilities:

Lead and mentor a group of PhD and non-PhD level scientists in the development and implementation of in vitro assay cascades that effectively identify optimal lead TRuC T cell candidates against various tumor-associated antigens, including TRuC T cells targeting multiple antigens

Apply a deep understanding of target biology and T cell immunology in the design of efficient screening strategies that interrogate TRuC T cell function and fitness/persistence

Accurately interpret complex in vitro data sets utilizing a thorough theoretical and practical knowledge of binder and target structure/function relationships

Continuously evaluate new technologies and assay formats for T cell functional characterization to increase the throughput, efficiency, and confidence in lead identification

Collaborate closely with the binder discovery, vector development and in vivo pharmacology teams to coordinate resources, manage program timelines and ensure quality delivery

Manage the preparation of data packages for lead nomination for presentation to internal stakeholders and external parties; author and prepare manuscripts for publication

May oversee the design and execution of IND-enabling in vitro pharmacology studies and preparation of associated non-clinical study reports

Requirements

Requirements:

Ph.D.* in immunology or similar discipline with 5+ years of post-Ph.D. research experience with 2+ years of experience developing CAR-T cells or similar engineered T cell platform, preferably in an industry setting

Experienced people manager and leader of cross-functional discovery teams

Demonstrated ability to empirically guide lead optimization strategies through applied knowledge of binder/target structure-function relationships; experience with binder optimization and through various approaches

Track record of success in leading functional binder screening efforts for engineered T cell therapies using various binder formats (scFv, sdAb or Fab)

Deep knowledge of T cell biology with keen insight into the biology of T cell effector function, differentiation/polarization, exhaustion/persistence and stimulatory/inhibitory regulatory mechanisms

High level of expertise in assays characterizing T cell phenotype and function, including but not limited to cytotoxicity, proliferation, cytokine production, chemotaxis, multiparameter immunophenotyping, and NGS analysis

Strong working understanding of tumor cell biology and strategies to overcome mechanisms of immune evasion

Experience in the design and execution of IND-enabling in vitro studies with a track record of IND submission success is highly desired

Must be a highly effective collaborator with strong written/verbal communication and interpersonal skills

*Candidates without a PhD may be considered if they have commensurate experience

Job Information

Job ID: 54650067

Location:

Cambridge, Massachusetts, United States

Position Title: Principal Scientist, Immunology Research

Company Name: TCR2 Therapeutics

Job Type: Full-Time

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Keywords: TCR2 Therapeutics, Cambridge , Principal Scientist, Immunology Research, Other , Cambridge, Massachusetts

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