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Senior Research Associate - Scientist I, Cell and Molecular Biology

Company: Syros Pharmaceuticals
Location: Cambridge
Posted on: March 28, 2020

Job Description:

Syros Pharmaceuticals is seeking a Cellular and Molecular Biologist to join a team of highly motivated scientists that are discovering new drug targets and developing small molecule modulators of fetal hemoglobin expression for the treatment of Sickle Cell Disease (SCD). In this lab-based position, the successful candidate will genetically and chemically interrogate cellular systems to support target and small molecule mechanism of action studies in erythroid cells. The successful candidate will also support hit validation, lead identification, and lead optimization efforts through screening for a variety of phenotypic markers in primary cells, cell lines and animal tissues.ResponsibilitiesCulture of human hematopoietic primary cells and immortalized cell lines Target knockdown and knockout experiments using shRNA and CRISPR/Cas9 Characterization of cell surface markers and intracellular proteins by flow cytometry Execution and analysis of small molecule phenotypic screens to support lead identification and optimizationIsolation of RNA from cells and animal tissues and detection of target mRNA levels Development of custom assays for nucleic acid and protein detectionDocumentation and communication of results in a timely mannerPresentation of study results in group and SCD project team meetingsSuccess FactorsStrong attention to detail and exceptional record keeping capabilitiesbility to think critically and creatively to solve problemsWillingness to learn and desire to work with sense of urgencyAbility to work effectively with cross-functional teams in a matrix environmentRequirementsBS/MS with at least 5 years of experience or entry-level PhD with 1 - 2 years of relevant experience. Title commensurate with experience.Proven core competency in standard cell and molecular biology techniquesSkilled in maintaining, troubleshooting, and optimizing cell culture systems Experience with hematopoietic and erythroid culture systems is a plusAbility to design, execute, and analyze qPCR and flow cytometry assays --Experience with lentiviral production/transduction and CRISPR/CAS9 delivery by nucleofectionCandidates who are keen experimentalists, independent thinkers, and enthusiastic team players that have a passion for drug discovery and elucidating novel biology are encouraged to apply.

Keywords: Syros Pharmaceuticals, Cambridge , Senior Research Associate - Scientist I, Cell and Molecular Biology, Other , Cambridge, Massachusetts

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