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Principal Scientist, AAV Process Development

Company: Intellia Therapeutics
Location: Cambridge
Posted on: March 27, 2020

Job Description:

At Intellia, we are revolutionizing medicine by harnessing the power of genome editing to develop potential cures. We bring new hope for people living with conditions including cancer, genetic disorders, viral infections, inflammatory disorders and many more.Summary:The ideal candidate will be an experienced Principal Scientist with a strong background in AAV production technology and characterization, and have an excellent track record of gene therapy process development including scale up and transfer to clinical manufacturing. This position is within the Technical Operations group and will support drug development programs requiring technology development and platform optimization for high yield, high quality AAV production at clinical scale for IND-enabling gene editing applications. The successful candidate will lead an innovative cell culture and purification development program integrated with analytical development and CMO technical transfer.Requirements:Drive process development of clinical scale AAV production and technical transfer to CMO.Implement or develop innovative vector production technologies based on QbD.Implement or develop analytical methods for the evaluation of critical AAV product attributes. Provide scientific expertise and guidance in clinical AAV production, development and innovation across the organization.Develop intellectual property, publishing scientific papers and other tasks related to the company's scientific and business interests.Qualifications:Ph.D. in Molecular Biology, Virology or related discipline with at least 5 years of post-PhD industrial experience in a drug development setting.Relevant MS with > 10 years of industrial experience will also be considered.Track record of leading a team of scientists and research associates.Experience with HEK triple transfection AAV production and upstream optimization.Experience with scaleable AAV purification technologies including affinity and full/empty capsid separation.Experience leading process development and scale up for GMP production in suspension cell bioreactors, chromatography, and filtration.Proficiency in AAV analytical technologies including ddPCR, and understanding of CQA and clinical release testing.Effective research and development team leadership.Effective inter-department coordination to meet project goals and timelines.Experience with QbD and GMP documentation in support of regulatory filings.Experience with production final fill technology and clinical stability studies a plus.Organized, detail-oriented, and a self-starter who continuously seeks innovative solutions.Excellent verbal and written communication skills.#LI-AL1What Intellia Stands For:At Intellia, our mission is to develop potentially curative genome editing treatments that can positively transform the lives of people living with severe and life-threating diseases.We push boundaries. We are focused on positively disrupting health care treatment of patients with genomic diseases. The values we live by and drivers we look for are:- One is respect for individuals; our unique qualities and strengths; our own ways to understand, learn and improve. One is our single-minded determination to excel; to succeed together. One is you and us - trusting and counting on every single one of us.- Explore because we seek new ways to tackle disease. Explore with unbounded minds...free from assumptions, open to ideas. Explore by staying curious, by pushing boundaries, overcoming obstacles. Explore means thinking of new ways.- Disrupt by thinking courageously...and creating a better future. Disrupt by defying conformity; interrogating the status quo; questioning our momentum. Disrupt with challenging thoughts...with that breed of skepticism that shows you have better solutions.- Deliver with your focus on the objective and your determination to complete the task. Deliver by advancing relentlessly and by maintaining high standards...even when nobody is watching. Deliver by staying accountable and pulling your weight. Deliver because patients are counting on us to make the promise reality. Get it done.POSITION: Full-Time, Exempt EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Keywords: Intellia Therapeutics, Cambridge , Principal Scientist, AAV Process Development, Other , Cambridge, Massachusetts

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