Scientist, Oncology in vivo Pharmacology

Company: Disability Solutions
Location: Cambridge
Posted on: September 1, 2024

Job Description:

Working with UsChallenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us .Position Summary: We are seeking an experienced lab-based in vivo scientist with Oncology drug discovery expertise to join the Oncology Discovery Pharmacology and in vivo Biology group within the Mechanisms of Cancer Resistance Thematic Research Center (MoCR TRC) at Bristol-Myers Squibb in Cambridge, MA. The qualified candidate is a highly motivated, proactive, and interactive scientist and with the ability to work across a highly matrixed organization to advance Oncology drug discovery programs from target validation to lead optimization, selection of drug candidate and IND-enabling in vivo experiments.This individual will be dedicated to designing and executing in vivo and ex vivo studies in tumored mouse models to support in vivo lead op all the way through IND filing. The successful candidate will collaborate closely with colleagues from in vitro Biology, Chemistry, Lead Optimization, DMPK, and Translational Research teams to deliver key in vivo datasets supporting the drug discovery portfolio at MoCR TRC. The candidate will be capable of presenting scientific results to program key stakeholders as well as the broader MoCR group.Detailed Position Responsibilities:In the role as a Scientist within Discovery Pharmacology and In Vivo Biology, the ideal candidate:

• Utilizes a variety of solid tumor CDX/PDX/GEMM models and drug administration routes to profile drug candidates and study MoA in tumor-bearing mice, independently conduct and analyze PKPD and Efficacy studies with small molecules and biologics.
• Utilizes a variety of ex vivo assays (MSD, Jess, Western Blot, qPCR, AlphaLisa etc) to interrogate in vivo PD response. Troubleshoot and optimize assays as needed.
• Accurately maintains proper scientific documentation associated with pharmacology studies in an electronic lab notebook.
• Routinely analyzes, organizes and presents study data using Microsoft Office and GraphPad.
• Utilizes excellent organization and communication skills. Effectively manage study timeline and coordinate study logistics with cross functional program teams.
• Understands department and program goals, and presents data in lab meetings, program and department meetings.
• Basic Qualifications:
  • Bachelor's Degree
    • 5+ years of academic and / or industry experienceOr
      • Master's Degree
        • 3+ years of academic and / or industry experienceOr
          • Ph.D. or equivalent advanced degree in the Life Sciences
            • No experience necessaryPreferred Qualifications:
              • A B.S. with a minimum of 7 years, or a M.S. with a minimum of 4 years of industry experience using in vivo Pharmacology approaches to drive Cancer Drug Discovery. This is a lab-based role.
              • Experience in Oncology small molecule drug discovery is required, experience with additional modalities is highly desired.
              • Demonstrated independence in designing, executing, and analyzing data from in vivo PKPD and efficacy studies with tumor bearing mice to profile drug candidates is required.
              • Proficiency with subcutaneous xenograft tumor models is required, experience with PDX, GEMM, or orthotopic models is highly desired.
              • Proficiency in cell culture, passaging and harvesting cells is required.
              • Highly skilled and proficient in the following in vivo Pharmacology techniques is required: tumor model development, subcutaneous tumor implantation, animal identification and randomization, murine dosing via PO, IP, IV, SC routes, tumor measurements by caliper, blood draws by tail vessel micro-sampling and cardiac puncture, tissue/tumor collection at necropsy including fixation, freezing and tissue disaggregation to support ex vivo analyses.
              • Skilled and proficient in the following techniques supporting ex vivo PD and biomarker discovery is required: tumor dissociation, DNA/RNA/protein extraction, ELISA (MSD), WB or Jess, qPCR.
              • Familiarity with cell line engineering (knock-out, knock-down, overexpression) is a plus.
                • Proficiency in utilizing software such as GraphPad Prism, electronic lab notebooks, Microsoft Office etc. for data analysis and figure generation is required.
                • Attention to detail with excellent organizational and record keeping skills.
                • Strong written and verbal communication skills with the ability to interact effectively with peers and management. Capable of presenting scientific results to multidisciplinary teams and key stakeholders.
                • Ability to contribute to the optimization of group workflows/SOPs, and ability to mentor junior associates and colleagues on best practices in the laboratory would be highly valued.
                • Highly motivated and ability to be flexible in case of changing priorities.
                • This position is located in Cambridge, MA. There will be less than 10% travel. If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. Uniquely Interesting Work, Life-changing CareersWith a single vision as inspiring as Transforming patients' lives through science--- , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.On-site Protocol BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role: Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function. BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com . Visit careers.bms.com/ eeo -accessibility to access our complete Equal Employment Opportunity statement. BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters. BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Keywords: Disability Solutions, Cambridge , Scientist, Oncology in vivo Pharmacology, Healthcare , Cambridge, Massachusetts