Principal Scientist, Computational Reverse Translation, Oncology Discovery
Company: Bristol Myers Squibb
Location: Cambridge
Posted on: March 18, 2023
Job Description:
Working with UsChallenging. Meaningful. Life-changing. Those
aren't words that are usually associated with a job. But working at
Bristol Myers Squibb is anything but usual. Here, uniquely
interesting work happens every day, in every department. From
optimizing a production line to the latest breakthroughs in cell
therapy, this is work that transforms the lives of patients, and
the careers of those who do it. You'll get the chance to grow and
thrive through opportunities uncommon in scale and scope, alongside
high-achieving teams rich in diversity. Take your career farther
than you thought possible.Bristol Myers Squibb recognizes the
importance of balance and flexibility in our work environment. We
offer a wide variety of competitive benefits, services and programs
that provide our employees with the resources to pursue their
goals, both at work and in their personal lives. Read more: We seek
a driven and communicative computational biology scientist with
experience in applying and translating machine learning approaches
to understand cancer biology and generate testable therapeutic
hypotheses. Our computational biology group partners with the
Mechanisms of Cancer Resistance (MoCR) center of BMS and is focused
on advancing BMS drug discovery pipeline through innovative
research bridging digital pathology and computational genomics
applied to data from cancer patient tissues. In collaboration with
an interdisciplinary team, we leverage multimodal pathology and
transcriptional data to propose new oncology targets and novel
disease biomarkers applicable in clinical trials. This position
offers the applicant an opportunity to interpret diverse patient
cohorts to propose and validate novel therapeutic disease
hypotheses and develop new applications for emerging spatial
technologies and functional validation technologies.Key
Responsibilities
- Develop and implement cutting-edge computational approaches for
the integration of multi-omics and multi-dimensional biological
datasets such as transcriptomics and pathology to drive hypotheses
generation and derive novel insights.
- As a part of an inter-disciplinary team, evaluate and advance
drug assets through the discovery pipeline at BMS.
- Engage with stakeholders across functional areas to define
scientific questions, drive experimental design and evaluate
emerging assays and platforms.
- Document and present results and analyses to stakeholders to
impact decision-making in early target identification and
translational research programs.
- Actively participate and contribute to BMS' internal research
community and research partnerships with academic groups.Basic
Qualifications
- Bachelor's Degree in Computational Biology, Bioinformatics,
Biostatistics, Systems Biology or other relevant fields and 8+
years of academic / industry experience
- OR Master's Degree in Computational Biology, Bioinformatics,
Biostatistics, Systems Biology or other relevant fields and 6+
years of academic / industry experience
- OR PhD in Computational Biology, Bioinformatics, Biostatistics,
Systems Biology or other relevant fields 4+ years of academic /
industry experiencePreferred Qualifications
- PhD and 4+ years of post-PhD research experience in
Computational Biology, Bioinformatics, Biostatistics, Systems
Biology or other relevant fields.
- Experience working in an inter-disciplinary environment that
warrants frequent collaborations and communication with peers and
leadership in biology, genomics, and computational teams.
- Demonstrated ability to thoughtfully evaluate and apply
statistical approaches and published algorithms to interpret
multi-omic data. In-depth knowledge of genomics analytical
approaches is highly desirable.
- Broad experience leveraging pathology assays (e.g., IHC and
mIF) and outputs to identify mechanism of action and biomarkers is
desirable.
- Practical knowledge of working with large clinical data cohorts
(e.g., TCGA) to investigate biology of a disease. Experience in
cancer genomics is highly preferred.
- Broad understanding of computational approaches to propose drug
target biomarkers, mechanisms of action, and translational
hypotheses is desirable.
- Excellent programming skills in R and/or Python. Knowledge of
reproducible research standards and tools (Git, JIRA) is highly
desirable.
- Excellent oral and written communication skills, with an
ability to explain computational approaches and resulting
conclusions to a diverse group of peers.If you come across a role
that intrigues you but doesn't perfectly line up with your resume,
we encourage you to apply anyway. You could be one step away from
work that will transform your life and career.Uniquely Interesting
Work, Life-changing CareersWith a single vision as inspiring as
"Transforming patients' lives through science--- ", every BMS
employee plays an integral role in work that goes far beyond
ordinary. Each of us is empowered to apply our individual talents
and unique perspectives in an inclusive culture, promoting
diversity in clinical trials, while our shared values of passion,
innovation, urgency, accountability, inclusion and integrity bring
out the highest potential of each of our colleagues.On-site
ProtocolPhysical presence at the BMS worksite or physical presence
in the field is a necessary job function of this role, which the
Company deems critical to collaboration, innovation, productivity,
employee well-being and engagement, and it enhances the Company
culture.COVID-19 InformationTo protect the safety of our workforce,
customers, patients and communities, the policy of the Company
requires all employees and workers in the U.S. and Puerto Rico to
be fully vaccinated against COVID-19, unless they have received an
exception based on an approved request for a medical or religious
reasonable accommodation. -Therefore, all BMS applicants seeking a
role located in the U.S. and Puerto Rico must confirm that they
have already received or are willing to receive the full COVID-19
vaccination by their start date as a qualification of the role and
condition of employment. -This requirement is subject to state and
local law restrictions and may not be applicable to employees
working in certain jurisdictions such as Montana. This requirement
is also subject to discussions with collective bargaining
representatives in the U.S.BMS is dedicated to ensuring that people
with disabilities can perform complex functions through a
transparent recruitment process, reasonable workplace adjustments
and ongoing support in their roles. Applicants can request an
accommodation prior to accepting a job offer. If you require
reasonable accommodation in completing this application, or in any
part of the recruitment process, direct your inquiries to . Visit
to access our complete Equal Employment Opportunity statement.BMS
will consider for employment qualified applicants with arrest and
conviction records, pursuant to applicable laws in your area.Any
data processed in connection with role applications will be treated
in accordance with applicable data privacy policies and
regulations.
Keywords: Bristol Myers Squibb, Cambridge , Principal Scientist, Computational Reverse Translation, Oncology Discovery, Healthcare , Cambridge, Massachusetts
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