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Principal Scientist, Computational Reverse Translation, Oncology Discovery

Company: Bristol Myers Squibb
Location: Cambridge
Posted on: March 18, 2023

Job Description:

Working with UsChallenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: We seek a driven and communicative computational biology scientist with experience in applying and translating machine learning approaches to understand cancer biology and generate testable therapeutic hypotheses. Our computational biology group partners with the Mechanisms of Cancer Resistance (MoCR) center of BMS and is focused on advancing BMS drug discovery pipeline through innovative research bridging digital pathology and computational genomics applied to data from cancer patient tissues. In collaboration with an interdisciplinary team, we leverage multimodal pathology and transcriptional data to propose new oncology targets and novel disease biomarkers applicable in clinical trials. This position offers the applicant an opportunity to interpret diverse patient cohorts to propose and validate novel therapeutic disease hypotheses and develop new applications for emerging spatial technologies and functional validation technologies.Key Responsibilities

  • Develop and implement cutting-edge computational approaches for the integration of multi-omics and multi-dimensional biological datasets such as transcriptomics and pathology to drive hypotheses generation and derive novel insights.
  • As a part of an inter-disciplinary team, evaluate and advance drug assets through the discovery pipeline at BMS.
  • Engage with stakeholders across functional areas to define scientific questions, drive experimental design and evaluate emerging assays and platforms.
  • Document and present results and analyses to stakeholders to impact decision-making in early target identification and translational research programs.
  • Actively participate and contribute to BMS' internal research community and research partnerships with academic groups.Basic Qualifications
    • Bachelor's Degree in Computational Biology, Bioinformatics, Biostatistics, Systems Biology or other relevant fields and 8+ years of academic / industry experience
    • OR Master's Degree in Computational Biology, Bioinformatics, Biostatistics, Systems Biology or other relevant fields and 6+ years of academic / industry experience
    • OR PhD in Computational Biology, Bioinformatics, Biostatistics, Systems Biology or other relevant fields 4+ years of academic / industry experiencePreferred Qualifications
      • PhD and 4+ years of post-PhD research experience in Computational Biology, Bioinformatics, Biostatistics, Systems Biology or other relevant fields.
      • Experience working in an inter-disciplinary environment that warrants frequent collaborations and communication with peers and leadership in biology, genomics, and computational teams.
      • Demonstrated ability to thoughtfully evaluate and apply statistical approaches and published algorithms to interpret multi-omic data. In-depth knowledge of genomics analytical approaches is highly desirable.
      • Broad experience leveraging pathology assays (e.g., IHC and mIF) and outputs to identify mechanism of action and biomarkers is desirable.
      • Practical knowledge of working with large clinical data cohorts (e.g., TCGA) to investigate biology of a disease. Experience in cancer genomics is highly preferred.
      • Broad understanding of computational approaches to propose drug target biomarkers, mechanisms of action, and translational hypotheses is desirable.
      • Excellent programming skills in R and/or Python. Knowledge of reproducible research standards and tools (Git, JIRA) is highly desirable.
      • Excellent oral and written communication skills, with an ability to explain computational approaches and resulting conclusions to a diverse group of peers.If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.Uniquely Interesting Work, Life-changing CareersWith a single vision as inspiring as "Transforming patients' lives through science--- ", every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.On-site ProtocolPhysical presence at the BMS worksite or physical presence in the field is a necessary job function of this role, which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and it enhances the Company culture.COVID-19 InformationTo protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. -Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. -This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.BMS is dedicated to ensuring that people with disabilities can perform complex functions through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application, or in any part of the recruitment process, direct your inquiries to . Visit to access our complete Equal Employment Opportunity statement.BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Keywords: Bristol Myers Squibb, Cambridge , Principal Scientist, Computational Reverse Translation, Oncology Discovery, Healthcare , Cambridge, Massachusetts

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